Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium

doi:10.3390/molecules27103205

IMR OpenIR

	Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium
	Chen, Danhong 1,2; Yu, Chengcheng 1,2; Ying, Ying 1,2; Luo, Yuanyi 3; Ren, Ling 4; Zhu, Caizhen 3; Yang, Ke 4; Wu, Buling 1,2; Liu, Qi 1,2
通讯作者	Wu, Buling(bulingwu@smu.edu.cn) ; Liu, Qi(liuqi0721@smu.edu.cn)
	2022-05-01
发表期刊	MOLECULES
卷号	27 期号:10 页码:17
摘要	Peri-implantitis can lead to implant failure. In this study, curcumin (CUR) was modified onto the copper-bearing titanium alloy (Cu-Ti) with the assistance of polydopamine (PDA) in order to study the bone immune response and subsequent osteogenesis. FE-SEM, XPS and water contact angle were utilized to characterize the coating surface. Bone marrow mesenchymal stem cells (BMSCs) and macrophages were cultured separately and together onto the CUR modified Cu-Ti. Cell activity, expression of relative genes and proteins, cell migration ability, and fluorescence staining of cells were performed. CUR modification slightly increased the activation of M1-type and M2-type cells under physiological conditions. In the inflammation state, CUR inhibited the overexpression of M1 macrophages and induced M2-type differentiation. In addition, the modification itself could provoke the expression of osteoblastic-related genes of BMSCs, while promoting the osteogenic differentiation of BMSCs through the activation of macrophages in both physiological and inflammatory states. The BMSCs migration was increased, the expression of osteogenic-related genes and proteins was up-regulated, and alkaline phosphatase activity (ALP) was increased. Thus, the modification of CUR can promote the osteointegration effect of Cu-Ti by bone immunomodulation and may, in addition, improve the success rate of implants.
关键词	curcumin copper-bearing titanium bone immunoregulation surface modification dental implant
资助者	National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Science and Technology Program Project of Guangzhou City ; College Students' Innovation and Entrepreneurship Training Program of Southern Medical University
DOI	10.3390/molecules27103205
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[52003112] ; National Natural Science Foundation of China[81870755] ; National Natural Science Foundation of China[31870954] ; Natural Science Foundation of Guangdong Province[2018030310411] ; Science and Technology Program Project of Guangzhou City[202102080314] ; College Students' Innovation and Entrepreneurship Training Program of Southern Medical University[202012121009]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000802529200001
出版者	MDPI
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/174237
专题	中国科学院金属研究所
通讯作者	Wu, Buling; Liu, Qi
作者单位	1.Southern Med Univ, Nanfang Hosp, Dept Stomatol, 1838 North Guangzhou Ave, Guangzhou 510515, Peoples R China 2.Southern Med Univ, Coll Stomatol, 1838 North Guangzhou Ave, Guangzhou 510515, Peoples R China 3.Shenzhen Univ, Coll Chem & Environm Engn, Inst Low Dimens Mat Genome Initiat, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Chen, Danhong,Yu, Chengcheng,Ying, Ying,et al. Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium[J]. MOLECULES,2022,27(10):17.
APA	Chen, Danhong.,Yu, Chengcheng.,Ying, Ying.,Luo, Yuanyi.,Ren, Ling.,...&Liu, Qi.(2022).Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium.MOLECULES,27(10),17.
MLA	Chen, Danhong,et al."Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium".MOLECULES 27.10(2022):17.