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Biodegradable Mg-based alloys: biological implications and restorative opportunities
Lin, Xiao1; Saijilafu1; Wu, Xiexing1; Wu, Kang1; Chen, Jianquan1; Tan, Lili2; Witte, Frank3,4; Yang, Huilin1; Mantovani, Diego5,6; Zhou, Huan7; Liang, Chunyong7; Yang, Qiang7,8; Yang, Ke2; Yang, Lei1,7
Corresponding AuthorYang, Ke(kyang@imr.ac.cn) ; Yang, Lei(ylei@hebut.edu.cn)
2022-06-16
Source PublicationINTERNATIONAL MATERIALS REVIEWS
ISSN0950-6608
Pages39
AbstractMg-based alloys as revolutionary implantable biomaterials have increasingly attracted considerable attention, owing to their biodegradability in vivo and beneficial effects on biological systems. The degradation process and products of Mg-based alloys have been reported to exhibit significant biological effects on host-tissue responses. However, these effects have not yet been fully understood. This review systemically summarizes and analyses the current understandings and recent research progress in this area. The primary focal points are the biological effects and related mechanisms associated with the degradation behaviour of Mg-based alloys. The biological impacts of the degradation products are elucidated and the arguable or controversial issues are also discussed, providing a pathway toward a greater understanding of the biological implications of Mg-based alloys. Furthermore, based on these biological implications, the restorative potential of Mg-based alloys for applications in tissue repair and regeneration is summarized. Finally, outlooks on biosafety evaluation and design strategies for Mg-based alloy implants are briefly discussed.
KeywordBiodegradability Mg-based alloys biomaterials orthopedics stent biological properties tissue engineering translational medicine
Funding OrganizationNational Key Researchand Development Program of China ; National Natural Science Foundation of China ; Suzhou Science and Technology Project ; China Postdoctoral Science Foundation ; Full-time Talents Program of Hebei Province of China ; Jiangsu Innovation and Entrepreneurship Program ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) ; Academician Expert Workstation of Yunnan Province of China ; Innovation Fund of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation of China
DOI10.1080/09506608.2022.2079367
Indexed BySCI
Language英语
Funding ProjectNational Key Researchand Development Program of China[2020YFC1107401] ; National Natural Science Foundation of China[82025025] ; National Natural Science Foundation of China[32171321] ; Suzhou Science and Technology Project[SYS2019022] ; China Postdoctoral Science Foundation[2020T130459] ; Full-time Talents Program of Hebei Province of China[2020HBQZYC012] ; Jiangsu Innovation and Entrepreneurship Program ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) ; Academician Expert Workstation of Yunnan Province of China[202205AF150025] ; Innovation Fund of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation of China[2021-NCRC-CXJJ-ZH-17]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000812128400001
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/174384
Collection中国科学院金属研究所
Corresponding AuthorYang, Ke; Yang, Lei
Affiliation1.Soochow Univ, Orthoped Inst, Affiliated Hosp 1, Dept Orthoped, Suzhou, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.Charite Univ Med Berlin, Julius Wolff Inst, Berlin Brandenburg Ctr Regenerat Therapies, Berlin, Germany
4.Charite Univ Med Berlin, Ctr Musculoskeletal Surg, Berlin Brandenburg Ctr Regenerat Therapies, Berlin, Germany
5.Laval Univ, Lab Biomat & Bioengn, CRC I, Dept Min Met Mat Engn, Quebec City, PQ, Canada
6.Laval Univ, CHU Quebec Res Ctr, Quebec City, PQ, Canada
7.Hebei Univ Technol, Ctr Hlth Sci & Engn CHSE, Sch Hlth Sci & Biomed Engn, Tianjin 300130, Peoples R China
8.Tianjin Univ, Tianjin Hosp, Dept Spine Surg, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Lin, Xiao,Saijilafu,Wu, Xiexing,et al. Biodegradable Mg-based alloys: biological implications and restorative opportunities[J]. INTERNATIONAL MATERIALS REVIEWS,2022:39.
APA Lin, Xiao.,Saijilafu.,Wu, Xiexing.,Wu, Kang.,Chen, Jianquan.,...&Yang, Lei.(2022).Biodegradable Mg-based alloys: biological implications and restorative opportunities.INTERNATIONAL MATERIALS REVIEWS,39.
MLA Lin, Xiao,et al."Biodegradable Mg-based alloys: biological implications and restorative opportunities".INTERNATIONAL MATERIALS REVIEWS (2022):39.
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