Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy

doi:10.1021/acsami.2c02802

IMR OpenIR

	Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy
	Liu, Hui 1,2; Xu, Daorong 3,4; Ma, Yuan 3,4; Qian, Jikun 3,4; Yang, Yinghui 5; Yu, Bin 3,4; Ren, Ling 1; Yang, Ke 1
通讯作者	Yu, Bin(yubin@smu.edu.cn) ; Ren, Ling(lren@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn)
	2022-05-04
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	14 期号:17 页码:19226-19240
摘要	The competition between cells integration and bacterial colonization determines the fate of implantations. To reveal the effects of clinical implant topographies on osteoblast differentiation and bacterial biofilm formation, a series of micron/ submicron/nano-hierarchical structures were created at pure titanium surfaces (Ti-I, Ti-II, Ti-III). It was found that the hierarchical structures promoted MC3T3-E1 cell differentiation through contact guidance and Ti-II processed the best osteogenic ability. Undesirably, hierarchical surfaces further accelerated the biofilm formation due to submicron structures with low interaction. To reduce the risk of bacterial infections, hierarchical structures were prepared on the antibacterial Cu-bearing titanium alloy surfaces (TiCu-I, TiCu-II, TiCu-III). Hierarchical topographies not only endowed TiCu surfaces with antibacterial trapping characteristics due to CuO doped in the outermost oxides layer but also shifted the corrosion behavior of TiCu alloy into activation-passivation, increasing the Cu-ion release rate and further promoting the osteogenic differentiation. TiCu-III possessed excellent antibacterial trapping ability and optimal osteogenic action. Finally, in the osteomyelitis-modeled mice, hierarchical topographies aggravated the bacterial infection around Ti implants, which entirely lost the osseointegration, while all of the TiCu surfaces significantly inhibited the infection and accelerated the formation of new bone tunnels around the implants. In vivo studies successfully confirmed the tuning mechanism of hierarchical topographies on the biological responses of bacteria and cells to the Ti and TiCu alloys, which would pave the way to develop novel biofunctionalized metal implants.
关键词	hierarchical topography copper-bearing titanium alloy surface modi fi cation antibacterial activity osseointegration orthopedic implant
资助者	National Natural Science Foundation ; National Key Research and Development Program of China ; Liaoning Revitalization Talents Program ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences
DOI	10.1021/acsami.2c02802
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation[31870954] ; National Natural Science Foundation[51631009] ; National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100601] ; Liaoning Revitalization Talents Program[XLYC1807069] ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences[174321KYSB20180006]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000813013100001
出版者	AMER CHEMICAL SOC
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/174411
专题	中国科学院金属研究所
通讯作者	Yu, Bin; Ren, Ling; Yang, Ke
作者单位	1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed Surg, Guangzhou 510515, Peoples R China 4.Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Bone & Cartilage Regenerat, Guangzhou 510515, Peoples R China 5.Silvan Med Ltd, Suzhou 215006, Peoples R China
推荐引用方式 GB/T 7714	Liu, Hui,Xu, Daorong,Ma, Yuan,et al. Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy[J]. ACS APPLIED MATERIALS & INTERFACES,2022,14(17):19226-19240.
APA	Liu, Hui.,Xu, Daorong.,Ma, Yuan.,Qian, Jikun.,Yang, Yinghui.,...&Yang, Ke.(2022).Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy.ACS APPLIED MATERIALS & INTERFACES,14(17),19226-19240.
MLA	Liu, Hui,et al."Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy".ACS APPLIED MATERIALS & INTERFACES 14.17(2022):19226-19240.