| Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy | |
| Liu, Hui1,2; Xu, Daorong3,4; Ma, Yuan3,4; Qian, Jikun3,4; Yang, Yinghui5; Yu, Bin3,4; Ren, Ling1; Yang, Ke1 | |
| Corresponding Author | Yu, Bin(yubin@smu.edu.cn) ; Ren, Ling(lren@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn) |
| 2022-05-04 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 14Issue:17Pages:19226-19240 |
| Abstract | The competition between cells integration and bacterial colonization determines the fate of implantations. To reveal the effects of clinical implant topographies on osteoblast differentiation and bacterial biofilm formation, a series of micron/ submicron/nano-hierarchical structures were created at pure titanium surfaces (Ti-I, Ti-II, Ti-III). It was found that the hierarchical structures promoted MC3T3-E1 cell differentiation through contact guidance and Ti-II processed the best osteogenic ability. Undesirably, hierarchical surfaces further accelerated the biofilm formation due to submicron structures with low interaction. To reduce the risk of bacterial infections, hierarchical structures were prepared on the antibacterial Cu-bearing titanium alloy surfaces (TiCu-I, TiCu-II, TiCu-III). Hierarchical topographies not only endowed TiCu surfaces with antibacterial trapping characteristics due to CuO doped in the outermost oxides layer but also shifted the corrosion behavior of TiCu alloy into activation-passivation, increasing the Cu-ion release rate and further promoting the osteogenic differentiation. TiCu-III possessed excellent antibacterial trapping ability and optimal osteogenic action. Finally, in the osteomyelitis-modeled mice, hierarchical topographies aggravated the bacterial infection around Ti implants, which entirely lost the osseointegration, while all of the TiCu surfaces significantly inhibited the infection and accelerated the formation of new bone tunnels around the implants. In vivo studies successfully confirmed the tuning mechanism of hierarchical topographies on the biological responses of bacteria and cells to the Ti and TiCu alloys, which would pave the way to develop novel biofunctionalized metal implants. |
| Keyword | hierarchical topography copper-bearing titanium alloy surface modi fi cation antibacterial activity osseointegration orthopedic implant |
| Funding Organization | National Natural Science Foundation ; National Key Research and Development Program of China ; Liaoning Revitalization Talents Program ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences |
| DOI | 10.1021/acsami.2c02802 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation[31870954] ; National Natural Science Foundation[51631009] ; National Key Research and Development Program of China[2018YFC1106601] ; National Key Research and Development Program of China[2016YFC1100601] ; Liaoning Revitalization Talents Program[XLYC1807069] ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences[174321KYSB20180006] |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS ID | WOS:000813013100001 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/174411 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Yu, Bin; Ren, Ling; Yang, Ke |
| Affiliation | 1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 3.Southern Med Univ, Nanfang Hosp, Dept Orthopaed, Div Orthopaed Surg, Guangzhou 510515, Peoples R China 4.Southern Med Univ, Nanfang Hosp, Guangdong Prov Key Lab Bone & Cartilage Regenerat, Guangzhou 510515, Peoples R China 5.Silvan Med Ltd, Suzhou 215006, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Hui,Xu, Daorong,Ma, Yuan,et al. Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy[J]. ACS APPLIED MATERIALS & INTERFACES,2022,14(17):19226-19240. |
| APA | Liu, Hui.,Xu, Daorong.,Ma, Yuan.,Qian, Jikun.,Yang, Yinghui.,...&Yang, Ke.(2022).Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy.ACS APPLIED MATERIALS & INTERFACES,14(17),19226-19240. |
| MLA | Liu, Hui,et al."Mechanisms of Hierarchical Topographies Tuning Bacteria and Cell Biological Responses to the Surfaces of Pure Titanium and Cu-Bearing Titanium Alloy".ACS APPLIED MATERIALS & INTERFACES 14.17(2022):19226-19240. |
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