Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation

doi:10.1021/acsapm.3c00234

IMR OpenIR

	Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation
	Zhao, Yanlong 1; Qian, Yifu 1; Wang, Haimang 1; Zhao, Weiwei 1,2,3,4,5; Zhao, Jing 6; Zhang, Hongyu 1
通讯作者	Zhang, Hongyu(zhanghyu@tsinghua.edu.cn)
	2023-05-08
发表期刊	ACS APPLIED POLYMER MATERIALS
ISSN	2637-6105
卷号	5 期号:6 页码:3999-4010
摘要	Endowing the implanted biomaterial with a wide range of functions, such as lubrication and antibacterial and anticoagulation properties, is essential for their safe clinical use. In the present study, based on the superlubrication mechanism of articular cartilage, a branched polyelectrolyte polymer (PEI-PMPC) was successfully synthesized based on tert-butyl hydroperoxide-initiated grafting polymerization and then applied to the biocompatible polyurethane (PU) surface. Specifically, the PU sheet was pretreated by polydopamine (PDA), and the PEI-PMPC polymer was grafted onto the PDAmodified PU surface by Schiff base reaction to generate a solid PDA/ PEI-PMPC coating. The unmodified and modified surfaces were characterized by Fourier transform infrared spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and surface zeta potential. To compare the lubrication, antibacterial behavior, and hemocompatibility, the relevant properties of the modified surfaces were evaluated by the tribological test, plate count method, surface morphology, hemolysis rate, activated partial thromboplastin time, and thrombin time. The experimental results demonstrated that the adhesion of bovine serum albumin, Escherichia coli, Staphylococcus aureus, platelets, and red blood cells was significantly decreased on the PEI-PMPC-modified PU surface compared with that of the unmodified PU surface. The multifunctional properties of the coating were attributed to the hydration layer formed by zwitterionic phosphorylcholine groups, and additionally, the cationic PEI served to kill the bacteria adhering to the surface. In summary, the bioinspired coating proposed in this study could potentially be used as a promising surface functionalization strategy for biomedical implants.
关键词	bioinspired coating surface functionalization hydration lubrication antibacterial property anticoagulation
资助者	National Natural Science Foundation of China ; Precision Medicine Foundation, Tsinghua University, China ; Capital's Funds for Health Improvement and Research ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China
DOI	10.1021/acsapm.3c00234
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[52022043] ; National Natural Science Foundation of China[52275199] ; Precision Medicine Foundation, Tsinghua University, China[10001020120] ; Capital's Funds for Health Improvement and Research[2020-2Z-40810] ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China[SKLT2022C18]
WOS研究方向	Materials Science ; Polymer Science
WOS类目	Materials Science, Multidisciplinary ; Polymer Science
WOS记录号	WOS:000988791900001
出版者	AMER CHEMICAL SOC
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/177956
专题	中国科学院金属研究所
通讯作者	Zhang, Hongyu
作者单位	1.Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol Adv Equipment, Beijing 100084, Peoples R China 2.Shandong Univ, Sch&Hosp Stomatol, Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China 3.Shandong Univ, Shandong Key Lab Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China 4.Shandong Univ, Shandong Engn Lab Dent Mat & Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China 5.Shandong Univ, Shandong Prov Clin Res Ctr Oral Dis, Jinan 250012, Shandong, Peoples R China 6.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yanlong,Qian, Yifu,Wang, Haimang,et al. Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation[J]. ACS APPLIED POLYMER MATERIALS,2023,5(6):3999-4010.
APA	Zhao, Yanlong,Qian, Yifu,Wang, Haimang,Zhao, Weiwei,Zhao, Jing,&Zhang, Hongyu.(2023).Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation.ACS APPLIED POLYMER MATERIALS,5(6),3999-4010.
MLA	Zhao, Yanlong,et al."Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation".ACS APPLIED POLYMER MATERIALS 5.6(2023):3999-4010.