Copper modified cobalt-chromium particles for attenuating wear particle induced-inflammation and osteoclastogenesis

doi:10.1016/j.bioadv.2023.213315

IMR OpenIR

	Copper modified cobalt-chromium particles for attenuating wear particle induced-inflammation and osteoclastogenesis
	Lu, Yanjin 1,2,6; Xu, Xiongcheng 3; Yang, Chunguang 5; Hosseinkhani, Saman 7; Zhang, Chenke 1,4; Luo, Kai 1,3; Tang, Kanglai ; Yang, Ke 4; Lin, Jinxin 1,6
通讯作者	Zhang, Chenke(zhangchenke1993@foxmail.com) ; Luo, Kai(uokai39@163.com) ; Lin, Jinxin(franklin@fjirsm.ac.cn)
	2023-04-01
发表期刊	BIOMATERIALS ADVANCES
卷号	147 页码:11
摘要	The nature of aseptic prosthetic loosening mainly relates to the wear particles that induce inflammation and subsequent osteoclastogenesis. The ideal approach to impede wear particle-induced osteolysis should minimize inflammation and osteoclastogenesis. In this work, Co29Cr9W3Cu particles were used as a research model for the first time to explore the response of Co29Cr9W3Cu particles to inflammatory response and osteoclast activation in vitro and in vivo by using Co29Cr9W particles as the control group. In vitro studies showed that the Co29Cr9W3Cu particles could promote the generation of M2-phenotype macrophages and increase the expres-sion level of anti-inflammatory factor IL-10, while inhibiting the formation of M1-phenotype macrophages and down-regulating the expression of inflammatory factors TNF-alpha , IL-6 and IL-1 beta; More importantly, the Co29Cr9W3Cu particles reduced the expression of NF-kappa B and downstream osteoclast related-specific transcrip-tion marker genes, such as TRAP , NFATc1 , and Cath-K; In vivo results indicated that the Co29Cr9W3Cu particles exposed to murine calvarial contributed to decreasing the amount of osteoclast and osteolysis area. These findings collectively demonstrated that Cu-bearing cobalt-chromium alloy may potentially delay the develop-ment of aseptic prosthetic loosening induced by wear particles, which is expected to provide evidence of Co29Cr9W3Cu alloy as an alternative material of joint implants with anti-wear associated osteolysis.
关键词	Inflammation Osteoclastogenesis Osteoclast Cu ion
资助者	National Natural Science Foundation of China ; Funds of Scientific and Technological Plan of Fujian Province ; Fujian Science & Tech-nology Innovation Laboratory for Optoelectronic Information of China
DOI	10.1016/j.bioadv.2023.213315
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51801198] ; Funds of Scientific and Technological Plan of Fujian Province[2020Y0083] ; Funds of Scientific and Technological Plan of Fujian Province[2020L3026] ; Fujian Science & Tech-nology Innovation Laboratory for Optoelectronic Information of China[2021ZZ111]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:000997255300001
出版者	ELSEVIER
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/178061
专题	中国科学院金属研究所
通讯作者	Zhang, Chenke; Luo, Kai; Lin, Jinxin
作者单位	1.Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Optoelect Mat Chem & Phys, Fuzhou 350001, Peoples R China 2.Fujian Normal Univ, Coll Photon & Elect Engn, Key Lab Optoelect Sci & Technol Med, Minist Educ,Fujian Prov Key Lab Photon Technol, Fuzhou 350117, Peoples R China 3.Fujian Med Univ, Sch & Hosp Stomatol, Res Ctr Oral Tissue Engn, Fuzhou 350001, Peoples R China 4.Army Mil Med Univ, Southwest Hosp, Sports Med Ctr, Dept Orthoped Surg, Chongqing, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang 110000, Peoples R China 6.Fujian Sci & Technol Innovat Lab Optoelect Informa, Fuzhou 350108, Fujian, Peoples R China 7.Tarbiat Modares Univ, Fac Biol Sci, Tehran, Iran
推荐引用方式 GB/T 7714	Lu, Yanjin,Xu, Xiongcheng,Yang, Chunguang,et al. Copper modified cobalt-chromium particles for attenuating wear particle induced-inflammation and osteoclastogenesis[J]. BIOMATERIALS ADVANCES,2023,147:11.
APA	Lu, Yanjin.,Xu, Xiongcheng.,Yang, Chunguang.,Hosseinkhani, Saman.,Zhang, Chenke.,...&Lin, Jinxin.(2023).Copper modified cobalt-chromium particles for attenuating wear particle induced-inflammation and osteoclastogenesis.BIOMATERIALS ADVANCES,147,11.
MLA	Lu, Yanjin,et al."Copper modified cobalt-chromium particles for attenuating wear particle induced-inflammation and osteoclastogenesis".BIOMATERIALS ADVANCES 147(2023):11.