Improved biological performance of low modulus Ti-24Nb-4Zr-7.9Sn implants due to surface modification by anodic oxidation

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	Improved biological performance of low modulus Ti-24Nb-4Zr-7.9Sn implants due to surface modification by anodic oxidation
	Y. Gao; B. Gao; R. Wang; J. Wu; L. J. Zhang; Y. L. Hao; X. J. Tao
	2009
发表期刊	Applied Surface Science
ISSN	0169-4332
卷号	255 期号:9 页码:5009-5015
摘要	Dental implants are usually made from commercially pure titanium or titanium alloys. The purpose of this study was to evaluate the influence of surface treatment to low modulus Ti-24Nb-4Zr-7.9Sn (TNZS) on cell and bone responses. The TNZS alloy samples were modified using anodic oxidation (AD). Surface oxide properties were characterized by using various surface analytic techniques, involving scanning electron microscopy (SEM) equipped with energy dispersive spectrometer (EDS), X-ray diffractometry (XRD) and surface profilometer. During the AD treatment, porous titanium oxide layer was formed and Ca ions were incorporated into the oxide layer. The viability and morphology of osteoblasts on Ca-incorporated TNZS were studied. The bone responses of Ca-incorporated TNZS were evaluated by pull-out tests and morphological analysis after implantation in rabbit tibiae. The non-treated Ti and TNZS samples were used as the control. Significant increases in cell viability and pull-out forces (p < 0.05) were observed for Ca-incorporated TNZS implants compared with those for the control groups. Porous structures supplied positive guidance cues for osteoblasts to attach. The enhanced cell and bone responses to Ca-incorporated TNZS implants could be explained by the surface chemistry and microtopography. (c) 2009 Elsevier B.V. All rights reserved.
部门归属	[gao, y.; gao, b.; wu, j.; zhang, l. j.] fourth mil med univ, sch stomatol, xian 710032, peoples r china. [wang, r.] navy outpatient dept, fengtai hlth ctr, beijing 100071, peoples r china. [hao, y. l.; tao, x. j.] chinese acad sci, inst met res, shenyang 110016, peoples r china.;gao, b (reprint author), fourth mil med univ, sch stomatol, xian 710032, peoples r china;gaobo_fmmu@163.com
关键词	Titanium Alloy Anodic Oxidation Biocompatibility Osteoblast Osseointegration In-vitro Titanium Surfaces Bone Response Osteoblast Calcium Behavior Alloy Topography Adsorption Attachment
URL	查看原文
WOS记录号	WOS:000263542700056
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/31929
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	Y. Gao,B. Gao,R. Wang,et al. Improved biological performance of low modulus Ti-24Nb-4Zr-7.9Sn implants due to surface modification by anodic oxidation[J]. Applied Surface Science,2009,255(9):5009-5015.
APA	Y. Gao.,B. Gao.,R. Wang.,J. Wu.,L. J. Zhang.,...&X. J. Tao.(2009).Improved biological performance of low modulus Ti-24Nb-4Zr-7.9Sn implants due to surface modification by anodic oxidation.Applied Surface Science,255(9),5009-5015.
MLA	Y. Gao,et al."Improved biological performance of low modulus Ti-24Nb-4Zr-7.9Sn implants due to surface modification by anodic oxidation".Applied Surface Science 255.9(2009):5009-5015.