In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model

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	In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model
	X. Lin; L. L. Tan; Q. Wang; G. D. Zhang; B. C. Zhang; K. Yang
	2013
发表期刊	Materials Science & Engineering C-Materials for Biological Applications
ISSN	0928-4931
卷号	33 期号:7 页码:3881-3888
摘要	Magnesium alloys were studied extensively as a class of biodegradable metallic materials for medical applications. In the present study, ZK60 magnesium alloy was considered as a candidate and the micro-arc oxidation (MAO) treatment was adopted in order to reduce the degradation rate of the alloy. The in vivo degradation behaviors and biological compatibilities of ZK60 alloys with and without MAO treatment were studied with a transcortical model in rabbits. The implant and the surrounding bone tissues were characterized by CT, SEM and histological methods at 2,4 and 12 weeks after the implantation. The results demonstrated that both the bare and MAO-coated ZK60 alloys completely degraded within 12 weeks in this animal model. The MAO coating decreased the degradation rate of ZK60 alloy and enhanced the response of the surrounding tissues within the first 2 weeks. After then, an acceleration of the degradation of the MAO-coated ZK60 alloy was observed. It was found that the alloy could be degraded before the complete degradation of the MAO coating, leading to the local peeling off of the coating. An in vivo degradation mechanism of the MAO-coated ZK60 alloy was proposed based on the experimental results. The severe localized degradation caused by the peeling off of the MAO coating was the main reason for the acceleration of the degradation of the MAO-coated ZK60 alloy. (C) 2013 Elsevier B.V. All rights reserved.
部门归属	[lin, xiao ; tan, lili ; zhang, bingchun ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [wang, qiang ; zhang, guangdao] china med univ, sch stomatol, shenyang 110002, peoples r china. ; yang, k (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china. ; kyang@imr.ac.cn
关键词	Magnesium Alloy Zk60 Micro-arc Oxidation Degradation In Vivo Calcium-phosphate Coatings Osteoclastic Resorption Vitro Degradation Corrosion Behavior Bone Response Implants Biocompatibility Zirconium Silicate Biology
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/71350
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	X. Lin,L. L. Tan,Q. Wang,et al. In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model[J]. Materials Science & Engineering C-Materials for Biological Applications,2013,33(7):3881-3888.
APA	X. Lin,L. L. Tan,Q. Wang,G. D. Zhang,B. C. Zhang,&K. Yang.(2013).In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model.Materials Science & Engineering C-Materials for Biological Applications,33(7),3881-3888.
MLA	X. Lin,et al."In vivo degradation and tissue compatibility of ZK60 magnesium alloy with micro-arc oxidation coating in a transcortical model".Materials Science & Engineering C-Materials for Biological Applications 33.7(2013):3881-3888.