Experimental data confirm numerical modeling of the degradation process of magnesium alloys stents

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	Experimental data confirm numerical modeling of the degradation process of magnesium alloys stents
	W. Wu; S. S. Chen; D. Gastaldi; L. Petrini; D. Mantovani; K. Yang; L. L. Tan; F. Migliavacca
	2013
发表期刊	Acta Biomaterialia
ISSN	1742-7061
卷号	9 期号:10 页码:8730-8739
摘要	Biodegradable magnesium alloy stents (MAS) could present improved long-term clinical performances over commercial bare metal or drug-eluting stents. However, MAS were found to show limited mechanical support for diseased vessels due to fast degradation. Optimizing stent design through finite element analysis (FEA) is an efficient way to improve such properties. Following previous FEA works on design optimization and degradation modeling of MAS, this work carried out an experimental validation for the developed FEA model, thus proving its practical applicability of simulating MAS degradation. Twelve stent samples of AZ31B were manufactured according to two MAS designs (an optimized one and a conventional one), with six samples of each design. All the samples were balloon expanded and subsequently immersed in D-Hanks' solution for a degradation test lasting 14 days. The experimental results showed that the samples of the optimized design had better corrosion resistance than those of the conventional design. Furthermore, the degradation process of the samples was dominated by uniform and stress corrosion. With the good match between the simulation and the experimental results, the work shows that the FEA numerical modeling constitutes an effective tool for design and thus the improvement of novel biodegradable MAS. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
部门归属	[wu, wei ; gastaldi, dario ; petrini, lorenza ; migliavacca, francesco] politecn milan, dept struct engn, lab biol struct mech, i-20133 milan, italy. [chen, shanshan ; yang, ke ; tan, lili] chinese acad sci, inst met res, div specialized mat & devices, shenyang 110016, peoples r china. [mantovani, diego] univ laval, dept min met & mat engn, lab biomat & bioengn, quebec city, pq g1v 0a6, canada. [mantovani, diego] univ laval, univ hosp res ctr, quebec city, pq g1v 0a6, canada. ; wu, w (reprint author), politecn milan, dept struct engn, lab biol struct mech, piazza leonardo da vinci 32, i-20133 milan, italy. ; wu@stru.polimi.it
关键词	Magnesium Alloy Stents Finite Element Analysis Design Optimization Model Validation Corrosion Simulated Body-fluid Coronary Stents Design Optimization Corrosion Behavior Artery
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/71588
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	W. Wu,S. S. Chen,D. Gastaldi,et al. Experimental data confirm numerical modeling of the degradation process of magnesium alloys stents[J]. Acta Biomaterialia,2013,9(10):8730-8739.
APA	W. Wu.,S. S. Chen.,D. Gastaldi.,L. Petrini.,D. Mantovani.,...&F. Migliavacca.(2013).Experimental data confirm numerical modeling of the degradation process of magnesium alloys stents.Acta Biomaterialia,9(10),8730-8739.
MLA	W. Wu,et al."Experimental data confirm numerical modeling of the degradation process of magnesium alloys stents".Acta Biomaterialia 9.10(2013):8730-8739.