Porous Titanium-6 Aluminum-4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly-Ether-Ether-Ketone Cage in Sheep Vertebral Fusion

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	Porous Titanium-6 Aluminum-4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly-Ether-Ether-Ketone Cage in Sheep Vertebral Fusion
	S. H. Wu; Y. Li; Y. Q. Zhang; X. K. Li; C. F. Yuan; Y. L. Hao; Z. Y. Zhang; Z. Guo
	2013
发表期刊	Artificial Organs
ISSN	0160-564X
卷号	37 期号:12 页码:E191-E201
摘要	Interbody fusion cages made of poly-ether-ether-ketone (PEEK) have been widely used in clinics for spinal disorders treatment; however, they do not integrate well with surrounding bone tissue. Ti-6Al-4V (Ti) has demonstrated greater osteoconductivity than PEEK, but the traditional Ti cage is generally limited by its much greater elastic modulus (110GPa) than natural bone (0.05-30GPa). In this study, we developed a porous Ti cage using electron beam melting (EBM) technique to reduce its elastic modulus and compared its spinal fusion efficacy with a PEEK cage in a preclinical sheep anterior cervical fusion model. A porous Ti cage possesses a fully interconnected porous structure (porosity: 68 +/- 5.3%; pore size: 710 +/- 42m) and a similar Young's modulus as natural bone (2.5 +/- 0.2GPa). When implanted in vivo, the porous Ti cage promoted fast bone ingrowth, achieving similar bone volume fraction at 6 months as the PEEK cage without autograft transplantation. Moreover, it promoted better osteointegration with higher degree (2-10x) of bone-material binding, demonstrated by histomorphometrical analysis, and significantly higher mechanical stability (P<0.01), shown by biomechanical testing. The porous Ti cage fabricated by EBM could achieve fast bone ingrowth. In addition, it had better osseointegration and superior mechanical stability than the conventional PEEK cage, demonstrating great potential for clinical application.
部门归属	[wu, su-hua ; li, yi ; zhang, yong-quan ; li, xiao-kang ; yuan, chao-fan ; guo, zheng] fourth mil med univ, dept orthoped, xijing hosp, xian 710032, peoples r china. [hao, yu-lin] chinese acad sci, inst met res, shenyang 110016, peoples r china. [zhang, zhi-yong] natl tissue engn ctr china, shanghai, peoples r china. ; guo, z (reprint author), fourth mil med univ, dept orthoped, xijing hosp, xian 710032, peoples r china. ; guozheng@fmmu.edu.cn
关键词	Porous Material Titanium-6 Aluminum-4 Vanadium Electron Beam Melting Intervertebral Fusion Fusion Cage Lumbar Interbody Fusion Polyetheretherketone Peek Cages Anterior Cervical Fusion Bone-graft Mechanical Evaluation In-vivo Osteoblasts Ti-6al-4v Implants Porosity
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/72406
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	S. H. Wu,Y. Li,Y. Q. Zhang,et al. Porous Titanium-6 Aluminum-4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly-Ether-Ether-Ketone Cage in Sheep Vertebral Fusion[J]. Artificial Organs,2013,37(12):E191-E201.
APA	S. H. Wu.,Y. Li.,Y. Q. Zhang.,X. K. Li.,C. F. Yuan.,...&Z. Guo.(2013).Porous Titanium-6 Aluminum-4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly-Ether-Ether-Ketone Cage in Sheep Vertebral Fusion.Artificial Organs,37(12),E191-E201.
MLA	S. H. Wu,et al."Porous Titanium-6 Aluminum-4 Vanadium Cage Has Better Osseointegration and Less Micromotion Than a Poly-Ether-Ether-Ketone Cage in Sheep Vertebral Fusion".Artificial Organs 37.12(2013):E191-E201.