Loss of mechanical properties in vivo and bone-implant interface strength of AZ31B magnesium alloy screws with Si-containing coating

IMR OpenIR

	Loss of mechanical properties in vivo and bone-implant interface strength of AZ31B magnesium alloy screws with Si-containing coating
	L. L. Tan; Q. Wang; X. Lin; P. Wan; G. D. Zhang; Q. Zhang; K. Yang
	2014
发表期刊	Acta Biomaterialia
ISSN	1742-7061
卷号	10 期号:5 页码:2333-2340
摘要	In this study the loss of mechanical properties and the interface strength of coated AZ31B magnesium alloy (a magnesium-aluminum alloy) screws with surrounding host tissues were investigated and compared with non-coated AZ31B, degradable polymer and biostable titanium alloy screws in a rabbit animal model after 1, 4, 12 and 21 weeks of implantation. The interface strength was evaluated in terms of the extraction torque required to back out the screws. The loss of mechanical properties over time was indicated by one-point bending load loss of the screws after these were extracted at different times. AZ31B samples with a silicon-containing coating had a decreased degradation rate and improved biological properties. The extraction torque of Ti6AI4V, poly-L-lactide (PLLA) and coated AZ31B increased significantly from 1 week to 4 weeks post-implantation, indicating a rapid osteosynthesis process over 3 weeks. The extraction torque of coated AZ31B increased with implantation time, and was higher than that of PLLA after 4 weeks of implantation, equalling that of Ti6AI4V at 12 weeks and was higher at 21 weeks. The bending loads of non-coated AZ31B and PLLA screws degraded sharply after implantation, and that of coated AZ31B degraded more slowly. The biodegradation mechanism, the coating to control the degradation rate and the bioactivity of magnesium alloys influencing the mechanical properties loss over time and bone-implant interface strength are discussed in this study and it is concluded that a suitable degradation rate will result in an improvement in the mechanical performance of magnesium alloys, making them more suitable for clinical application. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
部门归属	[tan, lili ; wang, qiang ; lin, xiao ; wan, peng ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china. [wang, qiang ; zhang, guangdao] china med univ, sch stomatol, shenyang 110002, peoples r china. [zhang, qiang] gen hosp peoples liberat army, dept orthopaed, beijing 100853, peoples r china. ; tan, ll (reprint author), chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china. ; lltan@imr.ac.cn ; kyang@imr.ac.cn
关键词	Magnesium Alloy Si-containing Coating Mechanical Properties Loss Bone-implant Interface Strength Degradation Behavior Mg Electrodeposition Hydroxyapatite Performance Silicon Vitro
URL	查看原文
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/72911
专题	中国科学院金属研究所
推荐引用方式 GB/T 7714	L. L. Tan,Q. Wang,X. Lin,et al. Loss of mechanical properties in vivo and bone-implant interface strength of AZ31B magnesium alloy screws with Si-containing coating[J]. Acta Biomaterialia,2014,10(5):2333-2340.
APA	L. L. Tan.,Q. Wang.,X. Lin.,P. Wan.,G. D. Zhang.,...&K. Yang.(2014).Loss of mechanical properties in vivo and bone-implant interface strength of AZ31B magnesium alloy screws with Si-containing coating.Acta Biomaterialia,10(5),2333-2340.
MLA	L. L. Tan,et al."Loss of mechanical properties in vivo and bone-implant interface strength of AZ31B magnesium alloy screws with Si-containing coating".Acta Biomaterialia 10.5(2014):2333-2340.