Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application

IMR OpenIR

	Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application
	Han, Junjie; Wan, Peng; Ge, Ye; Fan, Xinmin; Tan, Lili; Li, Jianjun; Yang, Ke; pwan@imr.ac.cn; kyang@imr.ac.cn
	2016
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
卷号	58 页码:799-811
摘要	Bone defects are very challenging in orthopedic practice. There are many practical and clinical shortcomings in the repair of the defect by using autografts, allografts or xenografts, which continue to motivate the search for better alternatives. The ideal bone grafts should provide mechanical support, fill osseous voids and enhance the bone healing. Biodegradable magnesium-strontium (Mg-Sr) alloys demonstrate good biocompatibility and osteoconductive properties, which are promising biomaterials for bone substitutes. The aim of this study was to evaluate and pair the degradation of Mg-Sr alloys for grafting with their clinical demands. The microstructure and performance of Mg-Sr alloys, in vitro degradation and biological properties including in vitro cytocompatibility and in vivo implantation were investigated. The results showed that the as-cast Mg-Sr alloy exhibited a rapid degradation rate compared with the as-extruded alloy due to the intergranular distribution of the second phase and micro-galvanic corrosion. However, the initial degradation could be tailored by the coating protection, which was proved to be cytocompatible and also suitable for bone repair observed by in vivo implantation. The integrated fracture calluses were formed and bridged the fracture gap without gas bubble accumulation, meanwhile the substitutes simultaneously degraded. In conclusion, the as-cast Mg-Sr alloy with coating is potential to be used for bone substitute alternative. (C) 2015 Elsevier B.V. All rights reserved.
部门归属	[han, junjie ; fan, xinmin] nanjing univ sci & technol, dept mat sci & engn, nanjing 210094, jiangsu, peoples r china ; [han, junjie ; wan, peng ; tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [ge, ye ; li, jianjun] china med univ, shengjing hosp, shenyang 100004, peoples r china
关键词	Bone Substitutes Magnesium Alloys Strontium Degradation In Vivo
资助者	National High Technology Research and Development Program of China (863 Program) [2015AA033701]; Chinese Academy of Sciences-Croucher Founding Scheme for Joint Laboratories [CAS 14303]
收录类别	sci
语种	英语
WOS记录号	WOS:000364247500095
引用统计	被引频次：56[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/75174
专题	中国科学院金属研究所
通讯作者	pwan@imr.ac.cn; kyang@imr.ac.cn
推荐引用方式 GB/T 7714	Han, Junjie,Wan, Peng,Ge, Ye,et al. Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,58:799-811.
APA	Han, Junjie.,Wan, Peng.,Ge, Ye.,Fan, Xinmin.,Tan, Lili.,...&kyang@imr.ac.cn.(2016).Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,58,799-811.
MLA	Han, Junjie,et al."Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 58(2016):799-811.