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Modified surface morphology of a novel Ti-24Nb-4Zr-7.9Sn titanium alloy via anodic oxidation for enhanced interfacial biocompatibility and osseointegration
Li, Xiang; Chen, Tao; Hu, Jing; Li, Shujun; Zou, Qin; Li, Yunfeng; Jiang, Nan; Li, Hui; Li, Jihua; Li, JH (reprint author), Sichuan Univ, West China Coll Stomatol, Chengdu 610041, Sichuan, Peoples R China.
2016-08-01
发表期刊COLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
卷号144页码:265-275
摘要The Ti-24Nb-4Zr-7.9Sn titanium alloy (Ti2448) has shown potential for use in biomedical implants, because this alloy possesses several important mechanical properties, such as a high fracture strength, low elastic modulus, and good corrosion resistance. In this study, we aimed to produce a hierarchical nano structure on the surface of Ti2448 to endow this alloy with favorable biological properties. The chemical composition of Ti2448 (64.0 wt% Ti, 23.9 wt% Nb, 3.9 wt% Zr, and 8.1 wt% Sn) gives this material electrochemical properties that lead to the generation of topographical features under standard anodic oxidation. We characterized the surface properties of pure Ti (Ti), nanotube-Ti (NT), Ti2448, and nanotube-Ti2448 (NTi2448) based on surface morphology (scanning electron microscopy and atomic force microscopy), chemical and phase compositions (X-ray diffraction and X-ray photoelectron spectroscopy), and wettability (water contact angle). We evaluated the biocompatibility and osteointegration of implant surfaces by observing the behavior of bone marrow stromal cells (BMSCs) cultured on the surfaces in vitro and conducting histological analysis after in vivo implantation of the modified materials. Our results showed that a hierarchical structure with a nanoscale bone-like layer was achieved along with nanotube formation on the Ti2448 surface. The surface characterization data suggested the superior biocompatibility of the NTi2448 surface in comparison with the Ti, NT, and Ti2448 surfaces. Moreover, the NTi2448 surface showed better biocompatibility for BMSCs in vitro and better osteointegration in vivo. Based on these results, we conclude that anodic oxidation facilitated the formation of a nanoscale bone-like structure and nanotubes on Ti2448. Unlike the modified titanium surfaces developed to date, the NTi2448 surface, which presents both mechanical compatibility and bioactivity, offers excellent biocompatibility and osteointegration, suggesting its potential for use in orthopedic applications. (C) 2016 Published by Elsevier B.V.
部门归属[li, xiang ; chen, tao ; hu, jing ; li, yunfeng ; jiang, nan ; li, hui ; li, jihua] sichuan univ, west china hosp stomatol, state key lab oral dis, chengdu 610041, peoples r china ; [li, xiang ; chen, tao ; hu, jing ; li, yunfeng ; jiang, nan ; li, hui ; li, jihua] sichuan univ, west china hosp stomatol, dept oral & maxillofacial surg, chengdu 610041, peoples r china ; [li, shujun] chinese acad sci, shenyang natl lab mat sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china ; [zou, qin] sichuan univ, res ctr nanobiomat, analyt & texting ctr, chengdu 610064, peoples r china
关键词Ti-24nb-4zr-7.9sn Anodic Oxidation Hierarchical Structure Biocompatibility Osteointegration
学科领域Biophysics ; Chemistry ; Materials Science
资助者Natural Science Foundation of China [31271032, 81470720]; China 973 funds [2012CB933900]
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/75779
专题中国科学院金属研究所
通讯作者Li, JH (reprint author), Sichuan Univ, West China Coll Stomatol, Chengdu 610041, Sichuan, Peoples R China.
推荐引用方式
GB/T 7714
Li, Xiang,Chen, Tao,Hu, Jing,et al. Modified surface morphology of a novel Ti-24Nb-4Zr-7.9Sn titanium alloy via anodic oxidation for enhanced interfacial biocompatibility and osseointegration[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016,144:265-275.
APA Li, Xiang.,Chen, Tao.,Hu, Jing.,Li, Shujun.,Zou, Qin.,...&Li, JH .(2016).Modified surface morphology of a novel Ti-24Nb-4Zr-7.9Sn titanium alloy via anodic oxidation for enhanced interfacial biocompatibility and osseointegration.COLLOIDS AND SURFACES B-BIOINTERFACES,144,265-275.
MLA Li, Xiang,et al."Modified surface morphology of a novel Ti-24Nb-4Zr-7.9Sn titanium alloy via anodic oxidation for enhanced interfacial biocompatibility and osseointegration".COLLOIDS AND SURFACES B-BIOINTERFACES 144(2016):265-275.
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