The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model

IMR OpenIR

	The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model
	Sun, Wei; Zhang, Guangdao; Tan, Lili; Yang, Ke; Ai, Hongjun; Ai, HJ (reprint author), China Med Univ, Sch Stomatol, Dept Prosthodont, 117 North Nanjing St, Shenyang 110001, Peoples R China.
	2016-06-01
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
卷号	63 页码:506-511
摘要	This study aimed to evaluate the effect of fluorine coated Mg alloy and clarify its mechanism in bone formation. We implanted the fluorine coated AZ31B Mg alloy screw (group F) in rabbit mandibular and femur in vivo. Untreated AZ31B Mg alloy screw (group A) and titanium screw (group T) were used as control. Then, scanning electron microscopy, the spectral energy distribution analysis, hard and decalcified bone tissues staining were performed. Immunohistochemistry was employed to examine the protein expressions of bone morphogenetic protein 2 (BMP-2) and collagen type I in the vicinity of the implant. Compared with the group A, the degradation of the alloy was reduced, the rates of Mg corrosion and Mg ion release were slowed down, and the depositions of calcium and phosphate increased in the group F in the early stage of implantation. Histological results showed that fluorine coated Mg alloy had well osteogenic activity and biocompatibility. Moreover, fluoride coating obviously up-regulated the expressions of collagen type I and BMP-2. This study confirmed that the fluorine coating might improve the corrosion resistance of AZ31B Mg alloy and promote bone formation by up-regulated the expressions of collagen type I and BMP-2. (C) 2016 Elsevier B.V. All rights reserved.
部门归属	[sun, wei ; zhang, guangdao ; ai, hongjun] china med univ, sch stomatol, dept prosthodont, 117 north nanjing st, shenyang 110001, peoples r china ; [tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
关键词	Fluorine Coated Az31b Magnesium Alloy Osteogenic Activity Corrosion Resistance Bone Morphogenetic Protein 2 Collagen Type i
学科领域	Materials Science
资助者	Shenyang Science and Technology Project [F15-139-9-38]
收录类别	sci
语种	英语
WOS记录号	WOS:000374916800057
引用统计	被引频次：66[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/75866
专题	中国科学院金属研究所
通讯作者	Ai, HJ (reprint author), China Med Univ, Sch Stomatol, Dept Prosthodont, 117 North Nanjing St, Shenyang 110001, Peoples R China.
推荐引用方式 GB/T 7714	Sun, Wei,Zhang, Guangdao,Tan, Lili,et al. The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,63:506-511.
APA	Sun, Wei,Zhang, Guangdao,Tan, Lili,Yang, Ke,Ai, Hongjun,&Ai, HJ .(2016).The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,63,506-511.
MLA	Sun, Wei,et al."The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 63(2016):506-511.