The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation

IMR OpenIR

	The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation
	Nune, KC; Misra, RDK; Li, SJ; Hao, YL; Zhang, W; Misra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
	2016-10-01
发表期刊	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN	1549-3296
卷号	104 期号:10 页码:2488-2501
摘要	The objective of the study is to fundamentally elucidate the biological response of 3D printed mesh structures subjected to plasma electrolytic oxidation process through the study of osteoblast functions. The cellular activity of plasma electrolytic-oxidized mesh structure was explored in terms of cell-to-cell communication involving proliferation, synthesis of extracellular and intracellular proteins, and mineralization. Upon plasma electrolytic oxidation of the mesh structure, a thin layer of bioactive titania with pore size 1-3 mu m was nucleated on the surface. The combination of microporous bioactive titania and interconnected porous architecture provided the desired pathway for supply of nutrients and oxygen to cells and tissue and a favorable osteogenic microenvironment for tissue on-growth and in-growth, in relation to the unmodified mesh structure. The formation of a confluent layer as envisaged via electron microscopy and quantitative assessment of the expression level of proteins (actin, vinculin, and fibronectin) point toward the determining role of surface-modified mesh structure in modulating osteoblasts functions. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2488-2501, 2016.
部门归属	[nune, k. c. ; misra, r. d. k.] univ texas el paso, dept met mat & biomed engn, biomat & biomed engn res lab, 500 w univ ave, el paso, tx 79968 usa ; [li, s. j. ; hao, y. l.] chinese acad sci, inst met res, shenyang natl lab mat sci, 72 wenhua rd, shenyang 110016, peoples r china ; [zhang, w.] chinese acad sci, inst met res, lab corros & protect, shenyang 110016, peoples r china
关键词	Micro-arc Oxidation Mesh Structure Ti6al4v Osteoblasts
学科领域	Engineering, Biomedical ; Materials Science, bioMaterials
资助者	863 project [2015AA033702]; Materials Science and Biomedical Engineering programs of the Department of Metallurgical, Materials, and Biomedical Engineering, University of Texas at El Paso
收录类别	sci
语种	英语
WOS记录号	WOS:000383861400011
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/76254
专题	中国科学院金属研究所
通讯作者	Misra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
推荐引用方式 GB/T 7714	Nune, KC,Misra, RDK,Li, SJ,et al. The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2016,104(10):2488-2501.
APA	Nune, KC,Misra, RDK,Li, SJ,Hao, YL,Zhang, W,&Misra, RDK .(2016).The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,104(10),2488-2501.
MLA	Nune, KC,et al."The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 104.10(2016):2488-2501.