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Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis
Liu, R; Memarzadeh, K; Chang, B; Zhang, YM; Ma, Z; Allaker, RP; Ren, L; Yang, K; Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.; Allaker, RP (reprint author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Newark St, London E1 2AT, England.
2016-07-26
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6
AbstractFormation of bacterial biofilms on dental implant material surfaces (titanium) may lead to the development of peri-implant diseases influencing the long term success of dental implants. In this study, a novel Cu-bearing titanium alloy (Ti-Cu) was designed and fabricated in order to efficiently kill bacteria and discourage formation of biofilms, and then inhibit bacterial infection and prevent implant failure, in comparison with pure Ti. Results from biofilm based gene expression studies, biofilm growth observation, bacterial viability measurements and morphological examination of bacteria, revealed antimicrobial/antibiofilm activities of Ti-Cu alloy against the oral specific bacterial species, Streptococcus mutans and Porphyromonas gingivalis. Proliferation and adhesion assays with mesenchymal stem cells, and measurement of the mean daily amount of Cu ion release demonstrated Ti-Cu alloy to be biocompatible. In conclusion, Ti-Cu alloy is a promising dental implant material with antimicrobial/antibiofilm activities and acceptable biocompatibility.
description.department[liu, rui] northeastern univ, 3-11 wenhua rd, shenyang 110819, peoples r china ; [liu, rui ; ma, zheng ; ren, ling ; yang, ke] chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china ; [memarzadeh, kaveh ; allaker, robert p.] queen mary univ london, barts & london sch med & dent, inst dent, newark st, london e1 2at, england ; [chang, bei ; zhang, yumei] fourth mil med univ, sch stomatol, dept prosthet dent, state key lab mil stomatol, xian 710032, peoples r china
Subject AreaMultidisciplinary Sciences
Funding OrganizationNational Natural Science Foundation [81301329, 81271957, 81530051]; Joint foundation of Liaoning Province Natural Science Foundation; Shenyang National Laboratory for materials science [2015021004]; Youth Innovation Promotion Association, CAS [2014168]; Dunhill Medical Trust [R360/0514]
Indexed Bysci
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/76321
Collection中国科学院金属研究所
Corresponding AuthorRen, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.; Allaker, RP (reprint author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Newark St, London E1 2AT, England.
Recommended Citation
GB/T 7714
Liu, R,Memarzadeh, K,Chang, B,et al. Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis[J]. SCIENTIFIC REPORTS,2016,6.
APA Liu, R.,Memarzadeh, K.,Chang, B.,Zhang, YM.,Ma, Z.,...&Allaker, RP .(2016).Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis.SCIENTIFIC REPORTS,6.
MLA Liu, R,et al."Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis".SCIENTIFIC REPORTS 6(2016).
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