Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis

IMR OpenIR

	Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis
	Liu, R; Memarzadeh, K; Chang, B; Zhang, YM; Ma, Z; Allaker, RP; Ren, L; Yang, K; Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.; Allaker, RP (reprint author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Newark St, London E1 2AT, England.
	2016-07-26
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	6
摘要	Formation of bacterial biofilms on dental implant material surfaces (titanium) may lead to the development of peri-implant diseases influencing the long term success of dental implants. In this study, a novel Cu-bearing titanium alloy (Ti-Cu) was designed and fabricated in order to efficiently kill bacteria and discourage formation of biofilms, and then inhibit bacterial infection and prevent implant failure, in comparison with pure Ti. Results from biofilm based gene expression studies, biofilm growth observation, bacterial viability measurements and morphological examination of bacteria, revealed antimicrobial/antibiofilm activities of Ti-Cu alloy against the oral specific bacterial species, Streptococcus mutans and Porphyromonas gingivalis. Proliferation and adhesion assays with mesenchymal stem cells, and measurement of the mean daily amount of Cu ion release demonstrated Ti-Cu alloy to be biocompatible. In conclusion, Ti-Cu alloy is a promising dental implant material with antimicrobial/antibiofilm activities and acceptable biocompatibility.
部门归属	[liu, rui] northeastern univ, 3-11 wenhua rd, shenyang 110819, peoples r china ; [liu, rui ; ma, zheng ; ren, ling ; yang, ke] chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china ; [memarzadeh, kaveh ; allaker, robert p.] queen mary univ london, barts & london sch med & dent, inst dent, newark st, london e1 2at, england ; [chang, bei ; zhang, yumei] fourth mil med univ, sch stomatol, dept prosthet dent, state key lab mil stomatol, xian 710032, peoples r china
学科领域	Multidisciplinary Sciences
资助者	National Natural Science Foundation [81301329, 81271957, 81530051]; Joint foundation of Liaoning Province Natural Science Foundation; Shenyang National Laboratory for materials science [2015021004]; Youth Innovation Promotion Association, CAS [2014168]; Dunhill Medical Trust [R360/0514]
收录类别	sci
语种	英语
WOS记录号	WOS:000380211800001
引用统计	被引频次：227[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/76321
专题	中国科学院金属研究所
通讯作者	Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.; Allaker, RP (reprint author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Newark St, London E1 2AT, England.
推荐引用方式 GB/T 7714	Liu, R,Memarzadeh, K,Chang, B,et al. Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis[J]. SCIENTIFIC REPORTS,2016,6.
APA	Liu, R.,Memarzadeh, K.,Chang, B.,Zhang, YM.,Ma, Z.,...&Allaker, RP .(2016).Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis.SCIENTIFIC REPORTS,6.
MLA	Liu, R,et al."Antibacterial effect of copper-bearing titanium alloy (Ti-Cu) against Streptococcus mutans and Porphyromonas gingivalis".SCIENTIFIC REPORTS 6(2016).