Advanced   Register
IMR OpenIR  > 中国科学院金属研究所  > 期刊论文

题名: Biocompatibility and neurotoxicity of magnesium alloys potentially used for neural repairs
作者: Fei, Jianjun;  Wen, Xiaoxiao;  Lin, Xiao;  Saijilafu;  Wang, Weihua;  Ren, Olga;  Chen, Xinjian;  Tan, Lili;  Yang, Ke;  Yang, Huilin;  Yang, Lei
发表日期: 2017-9-1
摘要: Nerve injury, especially the large-size nerve damage, is a serious problem affecting millions of people. Entubulation of two ends of the injured nerve by using an implantable device, e.g., nerve guidance conduit (NGC), to guide the regeneration of nerve tissue is a promising approach for treating the large-size nerve defect. Magnesium (Mg) and its alloys are biodegradable, conductive, and own good mechanical properties. Mg2+ ion, one of the main degradation products of Mg and its alloys, was reported to promote the proliferation of neural stem cells and their neurite production. Thus, Mg and its alloys are potential materials for fabricating the nerve repair implants, such as NGC or scaffold. However, the compatibility of Mg alloys to cells, especially neurons is not clear. In this work, NZ20 (Mg-2Nd-Zn), ZN20 (Mg-2Zn-Nd) and Mg-10Li magnesium alloys were selected for study, due to the improved mechanical properties of NZ20 and ZN20 alloys and bio-function of Li+ ions from Mg-10Li to nervous system, respectively. The degradation behavior and biocompatibility were studied by in vitro degradation test and cell adhesion assay, respectively. Specifically, the cytocompatibility to dorsal root ganglion (DRG) neurons, RF/6A choroid-retina endothelial cells, and osteoblasts in the cell culture media containing Mg alloy extracts were investigated. The results showed that Mg alloys degraded at different rates in cell culture media and artificial cerebrospinal fluid. The three alloy extracts showed negligible toxic effects on the endothelial cells and osteoblasts at short term (1 day), while NZ20 extract inhibited the proliferation of these two types of cells. The effect of Mg alloy extracts on cell proliferation was also concentration-dependent. For DRG neurons, ZN20 and Mg-10Li alloy extracts showed no neural toxicity compared with control group. The results of the present work show a potential and feasibility of Mg-10Li and ZN20 for nerve repair applications. (C) 2017 Elsevier B.V. All rights reserved.
刊名: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Appears in Collections:中国科学院金属研究所_期刊论文

Files in This Item:

There are no files associated with this item.




Recommended Citation:
Fei, Jianjun,Wen, Xiaoxiao,Lin, Xiao,et al. Biocompatibility And Neurotoxicity Of Magnesium Alloys Potentially Used For Neural Repairs[J]. Materials Science & Engineering C-materials For Biological Applications,2017,78:1155-1163.

SCI Citaion Data:
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Fei, Jianjun]'s Articles
 [Wen, Xiaoxiao]'s Articles
 [Lin, Xiao]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Fei, Jianjun]‘s Articles
 [Wen, Xiaoxiao]‘s Articles
 [Lin, Xiao]‘s Articles
Scirus search
 Similar articles in Scirus
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院金属研究所  -Feedback
Powered by CSpace