In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles

IMR OpenIR

	In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles
	Chen, Shanshan; Tan, Lili; Zhang, Bingchun; Xia, Yonghui; Xu, Ke; Yang, Ke; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
	2017-05-01
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	33 期号:5 页码:469-474
摘要	When an orthopedics device is implanted into bone injury site, it will contact the soft tissue (skeletal muscle, fascia, ligament etc.) except for bone. Magnesium based biodegradable metals are becoming an important research object in orthopedics due to their bioactivity to promote bone healing. In this study, pure Mg rods with and without chemical conversion coating were implanted into the muscle tissue of rabbits. Implants and their surrounding tissues were taken out for weight loss measurement, cross-sectional scanning electron microscopy observation, elemental distribution analysis and histological examination. The results showed that the chemical conversion coating would increase the in vivo corrosion resistance of pure Mg and decrease the accumulation of calcium (Ca) and phosphorus (P) elements around the implants. For the bare magnesium implant, both Ca and P contents in the surrounding tissues increased at the initial stage of implantation and then decreased at 12 weeks implantation, while for the magnesium with chemical conversion coating, Ca and P contents in the surrounding tissues decreased with the implantation time, but were not significant. The histological results demonstrated that there was no calcification in the muscle tissue with implantation of magnesium for up to 12 weeks. The chemical conversion coating not only increased the in vivo corrosion resistance of pure Mg, but also avoided the depositions of Ca and P in the surrounding tissues, meaning that pure magnesium should be bio-safe when contacting with muscle tissues. Copyright (C) 2017, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.; When an orthopedics device is implanted into bone injury site, it will contact the soft tissue (skeletal muscle, fascia, ligament etc.) except for bone. Magnesium based biodegradable metals are becoming an important research object in orthopedics due to their bioactivity to promote bone healing. In this study, pure Mg rods with and without chemical conversion coating were implanted into the muscle tissue of rabbits. Implants and their surrounding tissues were taken out for weight loss measurement, cross-sectional scanning electron microscopy observation, elemental distribution analysis and histological examination. The results showed that the chemical conversion coating would increase the in vivo corrosion resistance of pure Mg and decrease the accumulation of calcium (Ca) and phosphorus (P) elements around the implants. For the bare magnesium implant, both Ca and P contents in the surrounding tissues increased at the initial stage of implantation and then decreased at 12 weeks implantation, while for the magnesium with chemical conversion coating, Ca and P contents in the surrounding tissues decreased with the implantation time, but were not significant. The histological results demonstrated that there was no calcification in the muscle tissue with implantation of magnesium for up to 12 weeks. The chemical conversion coating not only increased the in vivo corrosion resistance of pure Mg, but also avoided the depositions of Ca and P in the surrounding tissues, meaning that pure magnesium should be bio-safe when contacting with muscle tissues. Copyright (C) 2017, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.
部门归属	[chen, shanshan ; tan, lili ; zhang, bingchun ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [xia, yonghui ; xu, ke] china med univ, dept radiol, affiliated hosp 1, key lab diagnost imaging & intervent radiol, shenyang 110001, liaoning provin, peoples r china
关键词	Pure Magnesium Degradation Behavior Histologic Response Muscle Tissue
学科领域	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
资助者	National Science & Technology Pillar Program of China [2012BAl18B01]; National Basic Research Program of China ("973 Program") [2012CB619101]; National Natural Science Foundation of China [81171443]; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
收录类别	SCI
语种	英语
WOS记录号	WOS:000403530500009
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/78151
专题	中国科学院金属研究所
通讯作者	Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
推荐引用方式 GB/T 7714	Chen, Shanshan,Tan, Lili,Zhang, Bingchun,et al. In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2017,33(5):469-474.
APA	Chen, Shanshan.,Tan, Lili.,Zhang, Bingchun.,Xia, Yonghui.,Xu, Ke.,...&Yang, K .(2017).In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,33(5),469-474.
MLA	Chen, Shanshan,et al."In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 33.5(2017):469-474.