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题名: Evaluation of the osteo-inductive potential of hollow three-dimensional magnesium-strontium substitutes for the bone grafting application
作者: Li, Mei;  Yang, Xuan;  Wang, Weidan;  Zhang, Yu;  Wan, Peng;  Yang, Ke;  Han, Yong
发表日期: 2017-4-1
摘要: Regeneration of bone defects is a clinical challenge that usually necessitates bone grafting materials. Limited bone supply and donor site morbidity limited the application of autografting, and improved biomaterials are needed to match the performance of autografts. Osteoinductive materials would be the perfect candidates for achieving this task. Strontium (Sr) is known to encourage bone formation and also prevent osteoporosis. Such twin requirements have motivated researchers to develop Sr-substituted biomaterials for orthopedic applications. The present study demonstrated a new concept of developing biodegradable and hollow three-dimensional magnesium strontium (Mg Sr) devices for grafting with their clinical demands. The microstructure and performance of Mg Sr devices, in vitro degradation and biological properties including in vitro cytocompatibility and osteoinductivity were investigated. The results showed that our Mg Sr devices exhibited good cytocompatibility and osteogenic effect To further investigate the underlying mechanisms, RT-PCR and Western Blotting assays were taken to analyze the expression level of osteogenesis-related genes and proteins, respectively. The results showed that our Mg Sr devices could both up-regulate the genes and proteins expression of the transcription factors of Runt-related transcription factor 2 (RUNX2) and Osterix (OSX), as well as alkaline phosphatase (ALP), Osteopontin (OPN), Collagen I (COL I) and Osteocalcin (OCN) significantly. Taken together, our innovation presented in this work demonstrated that the hollow three-dimensional Mg Sr substitutes had excellent biocompatibility and osteogenesis and could be potential candidates for bone grafting for future orthopedic applications. (C) 2016 Elsevier B.V. All rights reserved.
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Recommended Citation:
Li, Mei,Yang, Xuan,Wang, Weidan,et al. Evaluation Of The Osteo-inductive Potential Of Hollow Three-dimensional Magnesium-strontium Substitutes For The Bone Grafting Application[J]. Materials Science & Engineering C-materials For Biological Applications,2017,73:347-356.

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