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Cellular response of osteoblasts to low modulus Ti-24Nb-4Zr-8Sn alloy mesh structure
Nune, K. C.; Misra, R. D. K.; Li, S. J.; Hao, Y. L.; Yang, R.; Misra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
2017-03-01
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
Volume105Issue:3Pages:859-870
AbstractTitanium alloys (Ti-6Al-4V and Ti-6Al-7Nb) are widely used for implants, which are characterized by high elastic modulus (approximate to 110 GPa) with (+) structure and that may induce undesirable stress shielding effect and immune responses associated with the presence of toxic elements. In this regard, we have combined the attributes of a new alloy design and the concept of additive manufacturing to fabricate 3D scaffolds with an interconnected porous structure. The new alloy is a -type Ti-24Nb-4Zr-8Sn (Ti2448) alloy with significantly reduced modulus. In the present study, we explore the biological response of electron beam melted low modulus Ti2448 alloy porous mesh structure through the elucidation of bioactivity and osteoblast functions. The cellular activity was explored in terms of cell-to-cell communication involving proliferation, spreading, synthesis of extracellular and intracellular proteins, differentiation, and mineralization. The formation of fine apatite-like crystals on the surface during immersion test in simulated body fluid confirmed the bioactivity of the scaffold surface, which provided the favorable osteogenic microenvironment for cell-material interaction. The combination of unique surface chemistry and interconnected porous architecture provided the desired pathway for supply of nutrients and oxygen to cells and a favorable osteogenic micro-environment for incorporation (on-growth and in-growth) of osteoblasts. The proliferation and differentiation of pre-osteoblasts and their ability to form a well mineralized bone-like extracellular matrix (ECM) by secreting bone markers (ALP, calcium, etc.) over the struts of the scaffold point toward the determining role of unique surface chemistry and 3D architecture of the Ti2448 alloy mesh structure in modulating osteoblasts functions. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 859-870, 2017.; Titanium alloys (Ti-6Al-4V and Ti-6Al-7Nb) are widely used for implants, which are characterized by high elastic modulus (approximate to 110 GPa) with (+) structure and that may induce undesirable stress shielding effect and immune responses associated with the presence of toxic elements. In this regard, we have combined the attributes of a new alloy design and the concept of additive manufacturing to fabricate 3D scaffolds with an interconnected porous structure. The new alloy is a -type Ti-24Nb-4Zr-8Sn (Ti2448) alloy with significantly reduced modulus. In the present study, we explore the biological response of electron beam melted low modulus Ti2448 alloy porous mesh structure through the elucidation of bioactivity and osteoblast functions. The cellular activity was explored in terms of cell-to-cell communication involving proliferation, spreading, synthesis of extracellular and intracellular proteins, differentiation, and mineralization. The formation of fine apatite-like crystals on the surface during immersion test in simulated body fluid confirmed the bioactivity of the scaffold surface, which provided the favorable osteogenic microenvironment for cell-material interaction. The combination of unique surface chemistry and interconnected porous architecture provided the desired pathway for supply of nutrients and oxygen to cells and a favorable osteogenic micro-environment for incorporation (on-growth and in-growth) of osteoblasts. The proliferation and differentiation of pre-osteoblasts and their ability to form a well mineralized bone-like extracellular matrix (ECM) by secreting bone markers (ALP, calcium, etc.) over the struts of the scaffold point toward the determining role of unique surface chemistry and 3D architecture of the Ti2448 alloy mesh structure in modulating osteoblasts functions. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 859-870, 2017.
description.department[nune, k. c. ; misra, r. d. k.] univ texas el paso, dept met mat & biomed engn, biomat & biomed engn res lab, 500 w univ ave, el paso, tx 79968 usa ; [li, s. j. ; hao, y. l. ; yang, r.] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, peoples r china
KeywordTi-24nb-4zr-8sn Alloy Low Elastic Modulus Mesh Structure Osteoblasts Functions
Subject AreaEngineering, Biomedical ; Materials Science, bioMaterials
Funding OrganizationChinese MoST [2015AA033702, 2016YFC1102601]; National Natural Science Foundation of China [51271182]; University of Texas at El Paso
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/78272
Collection中国科学院金属研究所
Corresponding AuthorMisra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
Recommended Citation
GB/T 7714
Nune, K. C.,Misra, R. D. K.,Li, S. J.,et al. Cellular response of osteoblasts to low modulus Ti-24Nb-4Zr-8Sn alloy mesh structure[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2017,105(3):859-870.
APA Nune, K. C.,Misra, R. D. K.,Li, S. J.,Hao, Y. L.,Yang, R.,&Misra, RDK .(2017).Cellular response of osteoblasts to low modulus Ti-24Nb-4Zr-8Sn alloy mesh structure.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,105(3),859-870.
MLA Nune, K. C.,et al."Cellular response of osteoblasts to low modulus Ti-24Nb-4Zr-8Sn alloy mesh structure".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 105.3(2017):859-870.
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