PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy

IMR OpenIR

	PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy
	Liu, Xu; Zhang, Xing; Zhu, Mo; Lin, Guanghui; Liu, Jian; Zhou, Zhufa; Tian, Xin; Pan, Yue; Pan, Y (reprint author), Soochow Univ, Coll Chem Chem Engn & Mat Sci, State & Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China.; Tian, X (reprint author), Soochow Univ, Sch Radiat Med & Protect, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China.; Tian, X (reprint author), Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Peoples R China.
	2017-01-11
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	9 期号:1 页码:279-285
摘要	The integration of photothermal therapy (PTT) with radiation therapy (RT) in a single nanoscale platform is believed to have considerable potential for cancer therapy. In this work, the rationally designed PEGylated Au@Pt nanodendrites (NDs) have been developed as a-novel X-ray computed tomography (CT) and PTT/RT enhanced theranostic agent for cancer therapy. The absorption of Au@Pt NDs was turned to the near-infrared region with the growth of Pt nanobranches and thus enhances the efficacy of PTT. Furthermore, because of the high atomic number (high Z) of Au as well as Pt, Au@Pt NDs significantly enhanced lethal effects of RT by inducing a highly localized radiation dose within cancer cells. More importantly, the combination of Au@Pt ND-enhanced RT with PTT suppressed,cancer cell growth more efficiently than that RT or PTT alone did, indicating a synergistic effect. Meanwhile, the Au@Pt NDs also possess significant CT imaging signal enhancement that has the potential to guide PTT/RT for cancers. The integrated strategy significantly improved CT and PTT/RT of cancer cells with mild laser and radiation. Because of these advantages, Au@Pt NDs have become appealing and effective agents for cancer theranostic.; The integration of photothermal therapy (PTT) with radiation therapy (RT) in a single nanoscale platform is believed to have considerable potential for cancer therapy. In this work, the rationally designed PEGylated Au@Pt nanodendrites (NDs) have been developed as a-novel X-ray computed tomography (CT) and PTT/RT enhanced theranostic agent for cancer therapy. The absorption of Au@Pt NDs was turned to the near-infrared region with the growth of Pt nanobranches and thus enhances the efficacy of PTT. Furthermore, because of the high atomic number (high Z) of Au as well as Pt, Au@Pt NDs significantly enhanced lethal effects of RT by inducing a highly localized radiation dose within cancer cells. More importantly, the combination of Au@Pt ND-enhanced RT with PTT suppressed,cancer cell growth more efficiently than that RT or PTT alone did, indicating a synergistic effect. Meanwhile, the Au@Pt NDs also possess significant CT imaging signal enhancement that has the potential to guide PTT/RT for cancers. The integrated strategy significantly improved CT and PTT/RT of cancer cells with mild laser and radiation. Because of these advantages, Au@Pt NDs have become appealing and effective agents for cancer theranostic.
部门归属	[liu, xu ; zhou, zhufa ; pan, yue] soochow univ, coll chem chem engn & mat sci, state & local joint engn lab novel funct polymer, suzhou 215123, peoples r china ; [zhu, mo] soochow univ, affiliated hosp 1, dept radiol, 188 shi zi rd, suzhou 215006, peoples r china ; [zhang, xing] chinese acad sci, shenyang natl lab mat sci, inst met res, shenyang 110016, peoples r china ; [lin, guanghui] chinese acad sci, suzhou inst nanotech & nanobion, printable elect res ctr, suzhou 215123, peoples r china ; [liu, jian] soochow univ, inst funct nano & soft mat funsom, suzhou 215123, peoples r china ; [tian, xin] soochow univ, sch radiat med & protect, sch radiol & interdisciplinary sci rad x, suzhou 215123, peoples r china ; [tian, xin] soochow univ, collaborat innovat ctr radiat med jiangsu higher, suzhou 215123, peoples r china
关键词	Au@pt Nanodendrites Computed Tomography Photothermal Therapy Radiotherapy Synergistic Effect
学科领域	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
资助者	National Natural Science Foundation of China [51402203, 31300788, 31400862]; Natural Science Foundation of Jiangsu Province for Young Scholars [BK20140326]; China Postdoctoral Science Foundation [2015M571797]; Natural Science Foundation of Jiangsu Higher Education Institutions [14KJB430021]; Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
收录类别	SCI
语种	英语
WOS记录号	WOS:000392037400034
引用统计	被引频次：146[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/78344
专题	中国科学院金属研究所
通讯作者	Pan, Y (reprint author), Soochow Univ, Coll Chem Chem Engn & Mat Sci, State & Local Joint Engn Lab Novel Funct Polymer, Suzhou 215123, Peoples R China.; Tian, X (reprint author), Soochow Univ, Sch Radiat Med & Protect, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China.; Tian, X (reprint author), Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Peoples R China.
推荐引用方式 GB/T 7714	Liu, Xu,Zhang, Xing,Zhu, Mo,et al. PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(1):279-285.
APA	Liu, Xu.,Zhang, Xing.,Zhu, Mo.,Lin, Guanghui.,Liu, Jian.,...&Tian, X .(2017).PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy.ACS APPLIED MATERIALS & INTERFACES,9(1),279-285.
MLA	Liu, Xu,et al."PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy".ACS APPLIED MATERIALS & INTERFACES 9.1(2017):279-285.