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| Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy | |
| Yang, Yang; Lin, Yuanzhe; Di, Donghua; Zhang, Xing; Wang, Da; Zhao, Qinfu; Wang, Siling; Zhao, QF; Wang, SL (reprint author), Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China. | |
| 2017-12-15 | |
| Source Publication | ACADEMIC PRESS INC ELSEVIER SCIENCE
 |
| ISSN | 0021-9797 |
| Volume | 508Pages:323-331 |
| Abstract | In this paper, a redox-triggered drug delivery system of DOX/MSN-Au was prepared for chemo-photothermal synergistic therapy. The ultra-small gold nanoparticles (NPs) were appended to the openings of mesoporous silica nanoparticles (MSN) by Au-S bonds as the gatekeepers. Meanwhile, the gold NPs could be heated to high temperature by the near infrared (NIR) light irradiation, which is conducive to photothermal therapy. X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectrometer (FT-IR) spectra confirmed the formation of MSN-SH and MSN-Au. An in vitro NIR-induced photothermal study indicated that MSN-Au possessed concentration-dependent and power dependent photothermal conversion capacity. Doxorubicin (DOX) was selected as the model drug loaded in the MSN. In vitro drug release showed that DOX released faster in the presence of glutathione (GSH) or NIR laser irradiation than without GSH or NIR irradiation, which suggested that the system had potentials for redox-responsive and NIR-triggered drug release. Confocal Laser Scanning Microscope (CLSM) was performed to evaluate the cellular uptake performance of DOX/MSN-Au. The cytotoxicity assay indicated that DOX/MSN-Au had a synergistic therapeutic effect by the combination of chemotherapy and photothermal therapy. This work suggested that MSN-Au could be explored as a redox-triggered drug delivery system for the chemo-photothermal synergistic therapy. (C) 2017 Elsevier Inc. All rights reserved.; In this paper, a redox-triggered drug delivery system of DOX/MSN-Au was prepared for chemo-photothermal synergistic therapy. The ultra-small gold nanoparticles (NPs) were appended to the openings of mesoporous silica nanoparticles (MSN) by Au-S bonds as the gatekeepers. Meanwhile, the gold NPs could be heated to high temperature by the near infrared (NIR) light irradiation, which is conducive to photothermal therapy. X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectrometer (FT-IR) spectra confirmed the formation of MSN-SH and MSN-Au. An in vitro NIR-induced photothermal study indicated that MSN-Au possessed concentration-dependent and power dependent photothermal conversion capacity. Doxorubicin (DOX) was selected as the model drug loaded in the MSN. In vitro drug release showed that DOX released faster in the presence of glutathione (GSH) or NIR laser irradiation than without GSH or NIR irradiation, which suggested that the system had potentials for redox-responsive and NIR-triggered drug release. Confocal Laser Scanning Microscope (CLSM) was performed to evaluate the cellular uptake performance of DOX/MSN-Au. The cytotoxicity assay indicated that DOX/MSN-Au had a synergistic therapeutic effect by the combination of chemotherapy and photothermal therapy. This work suggested that MSN-Au could be explored as a redox-triggered drug delivery system for the chemo-photothermal synergistic therapy. (C) 2017 Elsevier Inc. All rights reserved. |
| description.department | [yang, yang ; lin, yuanzhe ; di, donghua ; wang, da ; zhao, qinfu ; wang, siling] shenyang pharmaceut univ, sch pharm, dept pharmaceut, 103 wenhua rd, shenyang 110016, liaoning, peoples r china ; [zhang, xing] chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, liaoning, peoples r china |
| Keyword | Mesoporous Silica Nanoparticles Gold Nanoparticles Photothermal Therapy Near-infrared Doxorubicin |
| Subject Area | Chemistry, Physical |
| Funding Organization | National Natural Science Foundation of China [81603058, 81473165]; Liaoning Provincial Key Laboratory of Drug Preparation Design & Evaluation of Liaoning Provincial Education Department [LZ2015068]; Doctoral Research Funding of Liaoning Province [201601146]; Career Development Program for Young Teachers in Shenyang Pharmaceutical University [ZQN2016025] |
| Indexed By | SCI |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/78931 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhao, QF; Wang, SL (reprint author), Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China. |
| Recommended Citation GB/T 7714 | Yang, Yang,Lin, Yuanzhe,Di, Donghua,et al. Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy[J]. ACADEMIC PRESS INC ELSEVIER SCIENCE,2017,508:323-331. |
| APA | Yang, Yang.,Lin, Yuanzhe.,Di, Donghua.,Zhang, Xing.,Wang, Da.,...&Wang, SL .(2017).Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy.ACADEMIC PRESS INC ELSEVIER SCIENCE,508,323-331. |
| MLA | Yang, Yang,et al."Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy".ACADEMIC PRESS INC ELSEVIER SCIENCE 508(2017):323-331. |
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