Advanced   Register
IMR OpenIR  > 中国科学院金属研究所  > 期刊论文

题名: Gold nanoparticle-gated mesoporous silica as redox-triggered drug delivery for chemo-photothermal synergistic therapy
作者: Yang, Yang;  Lin, Yuanzhe;  Di, Donghua;  Zhang, Xing;  Wang, Da;  Zhao, Qinfu;  Wang, Siling
发表日期: 2017-12-15
摘要: In this paper, a redox-triggered drug delivery system of DOX/MSN-Au was prepared for chemo-photothermal synergistic therapy. The ultra-small gold nanoparticles (NPs) were appended to the openings of mesoporous silica nanoparticles (MSN) by Au-S bonds as the gatekeepers. Meanwhile, the gold NPs could be heated to high temperature by the near infrared (NIR) light irradiation, which is conducive to photothermal therapy. X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectrometer (FT-IR) spectra confirmed the formation of MSN-SH and MSN-Au. An in vitro NIR-induced photothermal study indicated that MSN-Au possessed concentration-dependent and power dependent photothermal conversion capacity. Doxorubicin (DOX) was selected as the model drug loaded in the MSN. In vitro drug release showed that DOX released faster in the presence of glutathione (GSH) or NIR laser irradiation than without GSH or NIR irradiation, which suggested that the system had potentials for redox-responsive and NIR-triggered drug release. Confocal Laser Scanning Microscope (CLSM) was performed to evaluate the cellular uptake performance of DOX/MSN-Au. The cytotoxicity assay indicated that DOX/MSN-Au had a synergistic therapeutic effect by the combination of chemotherapy and photothermal therapy. This work suggested that MSN-Au could be explored as a redox-triggered drug delivery system for the chemo-photothermal synergistic therapy. (C) 2017 Elsevier Inc. All rights reserved.
刊名: ACADEMIC PRESS INC ELSEVIER SCIENCE
Appears in Collections:中国科学院金属研究所_期刊论文

Files in This Item:

There are no files associated with this item.




Recommended Citation:
Yang, Yang,Lin, Yuanzhe,Di, Donghua,et al. Gold Nanoparticle-gated Mesoporous Silica As Redox-triggered Drug Delivery For Chemo-photothermal Synergistic Therapy[J]. Academic Press Inc Elsevier Science,2017,508:323-331.

SCI Citaion Data:
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Yang, Yang]'s Articles
 [Lin, Yuanzhe]'s Articles
 [Di, Donghua]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Yang, Yang]‘s Articles
 [Lin, Yuanzhe]‘s Articles
 [Di, Donghua]‘s Articles
Scirus search
 Similar articles in Scirus
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院金属研究所  -Feedback
Powered by CSpace