Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects

IMR OpenIR

	Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects
	Nune, KC; Li, SJ; Misra, RDK; Misra, RDK (reprint author), Univ Texas El Paso, Mat & Biomed Engn Dept, Biomaterials Sci & Engn Lab Met, El Paso, TX 79968 USA.
	2018-04-01
发表期刊	SCIENCE CHINA-MATERIALS
ISSN	2095-8226
卷号	61 期号:4 页码:455-474
摘要	We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.; We elucidate here the process-structure-property relationships in three-dimensional (3D) implantable titanium alloy biomaterials processed by electron beam melting (EBM) that is based on the principle of additive manufacturing. The conventional methods for processing of biomedical devices including freeze casting and sintering are limited because of the difficulties in adaptation at the host site and difference in the micro/macrostructure, mechanical, and physical properties with the host tissue. In this regard, EBM has a unique advantage of processing patient-specific complex designs, which can be either obtained from the computed tomography (CT) scan of the defect site or through a computeraided design (CAD) program. This review introduces and summarizes the evolution and underlying reasons that have motivated 3D printing of scaffolds for tissue regeneration. The overview comprises of two parts for obtaining ultimate functionalities. The first part focuses on obtaining the ultimate functionalities in terms of mechanical properties of 3D titanium alloy scaffolds fabricated by EBM with different characteristics based on design, unit cell, processing parameters, scan speed, porosity, and heat treatment. The second part focuses on the advancement of enhancing biological responses of these 3D scaffolds and the influence of surface modification on cell-material interactions. The overview concludes with a discussion on the clinical trials of these 3D porous scaffolds illustrating their potential in meeting the current needs of the biomedical industry.
部门归属	[nune, krishna chaitanya ; misra, r. devesh kumar] univ texas el paso, mat & biomed engn dept, biomaterials sci & engn lab met, el paso, tx 79968 usa ; [li, shujun] chinese acad sci, inst met res, shenyang 11016, liaoning, peoples r china
关键词	Bmp-induced Osteogenesis Free-form Fabrication In-vivo Performance Porous Tantalum Bone Ingrowth Osteoblast Functions Dental Implants Stem-cells Pore-size Surface Modification
学科领域	Materials Science, Multidisciplinary
资助者	Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso; Key Research Program of Frontier Science, CAS [QYZDJ-SSW-JSC031-02]
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/79380
专题	中国科学院金属研究所
通讯作者	Misra, RDK (reprint author), Univ Texas El Paso, Mat & Biomed Engn Dept, Biomaterials Sci & Engn Lab Met, El Paso, TX 79968 USA.
推荐引用方式 GB/T 7714	Nune, KC,Li, SJ,Misra, RDK,et al. Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects[J]. SCIENCE CHINA-MATERIALS,2018,61(4):455-474.
APA	Nune, KC,Li, SJ,Misra, RDK,&Misra, RDK .(2018).Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects.SCIENCE CHINA-MATERIALS,61(4),455-474.
MLA	Nune, KC,et al."Advancements in three-dimensional titanium alloy mesh scaffolds fabricated by electron beam melting for biomedical devices: mechanical and biological aspects".SCIENCE CHINA-MATERIALS 61.4(2018):455-474.