Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy

IMR OpenIR

	Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy
	Li, T; He, Y; Zhou, JX; Tang, SQ; Yang, YS; Wang, XT; Li, T (reprint author), Shandong Acad Sci, Adv Mat Inst, Shandong Key Lab High Strength Lightweight Metall, Jinan 250014, Shandong, Peoples R China.; Wang, XT (reprint author), Univ Sci & Technol Beijing, Collaborat Innovat Ctr Steel Technol, Beijing 100083, Peoples R China.
	2018-03-15
发表期刊	MATERIALS LETTERS
ISSN	0167-577X
卷号	215 页码:200-202
摘要	Heretofore, the effects of scandium on the biocompatibility of biodegradable magnesium alloys are extremely limited recognized. In the present study, four Mg-1.5Zn-0.6Zr-xSc (x = 0, 0.2, 0.5, 1.0 wt%) alloys were fabricated and their hydrophilicity, cytotoxicity, and hemocompatibility were investigated. The contact angle measurements revealed that addition of Sc improved the hydrophilicity of the alloys. For biodegradable alloys, perfect hydrophilicity could promote the tissue attaching on implant surface, establishing a benign biological reaction and improving the therapeutic effectiveness. The viabilities of L-929 cells and SP2/0 cells for all the alloys were about 100% and 90% compared to negative control, respectively. No obvious differences existed in cell viabilities between different Sc contents. With increasing addition of Sc, the hemolysis percentages and the degree of platelet activation increased. It deteriorated the hemocompatibility of the alloys. Proteomics, genomics, and in vivo investigations are needed in the future to get more deep understandings of the biocompatibility of Sc. (C) 2017 Elsevier B.V. All rights reserved.; Heretofore, the effects of scandium on the biocompatibility of biodegradable magnesium alloys are extremely limited recognized. In the present study, four Mg-1.5Zn-0.6Zr-xSc (x = 0, 0.2, 0.5, 1.0 wt%) alloys were fabricated and their hydrophilicity, cytotoxicity, and hemocompatibility were investigated. The contact angle measurements revealed that addition of Sc improved the hydrophilicity of the alloys. For biodegradable alloys, perfect hydrophilicity could promote the tissue attaching on implant surface, establishing a benign biological reaction and improving the therapeutic effectiveness. The viabilities of L-929 cells and SP2/0 cells for all the alloys were about 100% and 90% compared to negative control, respectively. No obvious differences existed in cell viabilities between different Sc contents. With increasing addition of Sc, the hemolysis percentages and the degree of platelet activation increased. It deteriorated the hemocompatibility of the alloys. Proteomics, genomics, and in vivo investigations are needed in the future to get more deep understandings of the biocompatibility of Sc. (C) 2017 Elsevier B.V. All rights reserved.
部门归属	[li, tao ; zhou, jixue ; tang, shouqiu ; yang, yuansheng] shandong acad sci, adv mat inst, shandong key lab high strength lightweight metall, jinan 250014, shandong, peoples r china ; [li, tao ; yang, yuansheng] chinese acad sci, inst met res, shenyang 110016, liaoning, peoples r china ; [li, tao ; he, yong] univ sci & technol beijing, state key lab adv met & mat, beijing 100083, peoples r china ; [wang, xitao] univ sci & technol beijing, collaborat innovat ctr steel technol, beijing 100083, peoples r china
关键词	Rare-earth-elements In-vitro Degradation Magnesium Alloys Cell-lines Corrosion Behavior Microstructure Implants Metals
学科领域	Materials Science, Multidisciplinary ; Physics, Applied
资助者	National Natural Science Foundation of China [51174025]; National Key Research and Development Program of China [2016YFB0301105]; Shandong Academy of Sciences of China [2018QN0034]; Shandong Provincial Natural Science Foundation of China [ZR2017LEM002]
收录类别	SCI
语种	英语
WOS记录号	WOS:000424709600053
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/79428
专题	中国科学院金属研究所
通讯作者	Li, T (reprint author), Shandong Acad Sci, Adv Mat Inst, Shandong Key Lab High Strength Lightweight Metall, Jinan 250014, Shandong, Peoples R China.; Wang, XT (reprint author), Univ Sci & Technol Beijing, Collaborat Innovat Ctr Steel Technol, Beijing 100083, Peoples R China.
推荐引用方式 GB/T 7714	Li, T,He, Y,Zhou, JX,et al. Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy[J]. MATERIALS LETTERS,2018,215:200-202.
APA	Li, T.,He, Y.,Zhou, JX.,Tang, SQ.,Yang, YS.,...&Wang, XT .(2018).Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy.MATERIALS LETTERS,215,200-202.
MLA	Li, T,et al."Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy".MATERIALS LETTERS 215(2018):200-202.