| A three-component one-pot synthesis of 2-alkoxy-4-amino-N-arylthiazole-5-carboxamides | |
| Alternative Title | A three-component one-pot synthesis of 2-alkoxy-4-amino-N-arylthiazole-5-carboxamides |
| Zhao HaiLong1; Zhou Jie1; Song HongRui3; Xu BaiLing1 | |
| 2014 | |
| Source Publication | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| Volume | 25Issue:3Pages:411-414 |
| Abstract | A facile and efficient protocol was developed to access 2-alkoxy-4-amino-N-aryithiazole-5-carboxamides through a three-component one-pot reaction, which involved potassium methyl cyanimidodithiocarbonate, 2-halo-N-arylacetamides and alcohols. The easy availability and the broad structural diversity of substrates make the reaction useful for the construction of libraries in drug discovery. (C) 2013 Bai-Ling Xu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Other Abstract | A facile and efficient protocol was developed to access 2-alkoxy-4-amino-N-arylthiazole-5-carboxamides through a three-component one-pot reaction, which involved potassium methyl cyanimidodithiocarbonate, 2-halo-N-arylacetamides and alcohols. The easy availability and the broad structural diversity of substrates make the reaction useful for the construction of libraries in drug discovery. |
| Keyword | HUMAN PIN1 INHIBITORS BIOLOGICAL EVALUATION DERIVATIVES AGENTS 4-Aminothiazole-5-carboxamide Potassium methyl cyanimidodithiocarbonate Acetamide |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Natural Science Foundation of China] ; ["863" Program of China] |
| CSCD ID | CSCD:5069001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/142703 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 1.Chinese Acad Med Sci, Institute Mat Med, Beijing Key Lab Act Subst Discovery & Drug Evalua, Beijing 100050, Peoples R China Institute Mat Med Beijing Key Lab Act Subst Discovery & Drug Evalua 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhao HaiLong,Zhou Jie,Song HongRui,et al. A three-component one-pot synthesis of 2-alkoxy-4-amino-N-arylthiazole-5-carboxamides[J]. CHINESE CHEMICAL LETTERS,2014,25(3):411-414. |
| APA | Zhao HaiLong,Zhou Jie,Song HongRui,&Xu BaiLing.(2014).A three-component one-pot synthesis of 2-alkoxy-4-amino-N-arylthiazole-5-carboxamides.CHINESE CHEMICAL LETTERS,25(3),411-414. |
| MLA | Zhao HaiLong,et al."A three-component one-pot synthesis of 2-alkoxy-4-amino-N-arylthiazole-5-carboxamides".CHINESE CHEMICAL LETTERS 25.3(2014):411-414. |
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