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Phase II metabolites of etofesalamide in filamentous fungi
Alternative TitlePhase II metabolites of etofesalamide in filamentous fungi
Huang HH; Ma GL; Sun YM; Li Q; Zhong DF
2005
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume26Issue:7Pages:893-896
AbstractAim: To study phase II metabolites of etofesalamide in filamentous fungi. Methods: Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure. Results: Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected. Conclusion: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals.
Other AbstractTo study phase II metabolites of etofesalamide in filamentous fungi. Methods: Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure. Results: Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected. Conclusion: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals.
KeywordCUNNINGHAMELLA-ELEGANS TRANSFORMATION etofesalamide Cunninghamella metabolite transformation mass spectrum analysis
Indexed ByCSCD
Language英语
CSCD IDCSCD:2208856
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/143351
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Huang HH,Ma GL,Sun YM,et al. Phase II metabolites of etofesalamide in filamentous fungi[J]. ACTA PHARMACOLOGICA SINICA,2005,26(7):893-896.
APA Huang HH,Ma GL,Sun YM,Li Q,&Zhong DF.(2005).Phase II metabolites of etofesalamide in filamentous fungi.ACTA PHARMACOLOGICA SINICA,26(7),893-896.
MLA Huang HH,et al."Phase II metabolites of etofesalamide in filamentous fungi".ACTA PHARMACOLOGICA SINICA 26.7(2005):893-896.
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