| Phase II metabolites of etofesalamide in filamentous fungi | |
| Alternative Title | Phase II metabolites of etofesalamide in filamentous fungi |
| Huang HH; Ma GL; Sun YM; Li Q; Zhong DF | |
| 2005 | |
| Source Publication | ACTA PHARMACOLOGICA SINICA
 |
| ISSN | 1671-4083 |
| Volume | 26Issue:7Pages:893-896 |
| Abstract | Aim: To study phase II metabolites of etofesalamide in filamentous fungi. Methods: Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure. Results: Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected. Conclusion: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals. |
| Other Abstract | To study phase II metabolites of etofesalamide in filamentous fungi. Methods: Seven fungi were screened to transform etofesalamide. The metabolites of etofesalamide were assayed using liquid chromatography coupled to mass spectrometry. The major metabolite was subject to enzymatic hydrolysis to confirm its structure. Results: Etofesalamide was converted into two phase II metabolites: glucoside and riboside conjugates. Glucoside conjugate was the major product with a yield greater than 90%; no phase I metabolites were detected. Conclusion: Glucoside and riboside conjugations of etofesalamide in filamentous fungi differ from the phase II metabolism of glucuronidation in mammals. |
| Keyword | CUNNINGHAMELLA-ELEGANS TRANSFORMATION etofesalamide Cunninghamella metabolite transformation mass spectrum analysis |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:2208856 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/143351 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Huang HH,Ma GL,Sun YM,et al. Phase II metabolites of etofesalamide in filamentous fungi[J]. ACTA PHARMACOLOGICA SINICA,2005,26(7):893-896. |
| APA | Huang HH,Ma GL,Sun YM,Li Q,&Zhong DF.(2005).Phase II metabolites of etofesalamide in filamentous fungi.ACTA PHARMACOLOGICA SINICA,26(7),893-896. |
| MLA | Huang HH,et al."Phase II metabolites of etofesalamide in filamentous fungi".ACTA PHARMACOLOGICA SINICA 26.7(2005):893-896. |
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