| Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats | |
| Alternative Title | Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats |
| Qiu F; Chen XY; Song B; Zhong DF; Liu CX | |
| 2005 | |
| Source Publication | ACTA PHARMACOLOGICA SINICA
 |
| ISSN | 1671-4083 |
| Volume | 26Issue:9Pages:1145-1152 |
| Abstract | Aim: To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats. |
| Other Abstract | Aim： To investigate the influence of dosage forms on the pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in Wistar rats. Methods： After administration of two typical dosage forms （daidzein solution and suspension）, the concentrations of daidzein and daidzein-7-O-glucuronide were determined by an LC-MS-MS method. The pharmacokinetic parameters were calculated and analyzed statistically using the Student＇s t-test. Results： Absorption of daidzein after administration of daidzein solution （tmax=0.46 h） was more rapid than that of the suspension （tmax=5.00 h）. The peak plasma concentrations of daidzein after administration of daidzein solution and suspension were 601.1 μg/L and 127.3 μg/L, respectively, and those of daidzein-7-O-glucuronide were 3000 μg/L and 192.6 μg/L, respectively. The absolute bioavailabilities of free daidzein in rats after administration of daidzein solution and suspension were 12.8% and 6.1%, respectively, which were calculated to be 47.0% and 12.2%, respectively, in the form of total daidzein （free plus conjugated daidzein）. Conclusion： Absorption of daidzein solution was better than absorption of suspension （P〈0.05）. |
| Keyword | PURIFIED SOY ISOFLAVONES CLINICAL CHARACTERISTICS LIQUID-CHROMATOGRAPHY PREMENOPAUSAL WOMEN PLASMA MEN GENISTEIN URINE daidzein daidzein-7-O-glucuronide influence dosage forms pharmacokinetics rats |
| Indexed By | CSCD |
| Language | 英语 |
| CSCD ID | CSCD:2208518 |
| Citation statistics |
Cited Times:5[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/146540 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Qiu F,Chen XY,Song B,et al. Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats[J]. ACTA PHARMACOLOGICA SINICA,2005,26(9):1145-1152. |
| APA | Qiu F,Chen XY,Song B,Zhong DF,&Liu CX.(2005).Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats.ACTA PHARMACOLOGICA SINICA,26(9),1145-1152. |
| MLA | Qiu F,et al."Influence of dosage forms on pharmacokinetics of daidzein and its main metabolite daidzein-7-O-glucuronide in rats".ACTA PHARMACOLOGICA SINICA 26.9(2005):1145-1152. |
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