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Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats
Alternative TitleFluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats
Li Xueqin1; Wang Hanming1; Yang Chunguang1; Zhang Xinhua1; Han Dandan1; Wang Huailiang1
2011
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume32Issue:2Pages:217-222
AbstractAim: To investigate the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine on extracellular matrix (ECM) remodeling of the pulmonary artery and inflammation of the lungs in pulmonary arterial hypertension (PAH) induced by monocrotaline in rats.
Other AbstractAim: To investigate the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine on extracellular matrix (ECM) remodeling of the pulmonary artery and inflammation of the lungs in pulmonary arterial hypertension (PAH) induced by monocrotaline in rats. Methods: MCT-induced chronic PAH was established in Wistar rats. After treatment with fluoxetine for 3 weeks, pulmonary hemodynamic measurement and morphological investigation of lung tissues were undertaken. The main components of the ECM, elastin and collagen, were detected using Van Gieson stain and Orcein stain, respectively, or using Victoria-ponceau's double stain. The ECM proteolytic enzymes matrix metalloproteinase (MMP)-2 and MMP-9, and the tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2, were detected by Western blot. Inflammation of lung tissue was assayed using lung morphology and inflammatory cytokine expression. Results: Fluoxetine (2 and 10 mg Conclusion: Fluoxetine inhibited MCT-induced ECM remodeling of the pulmonary artery and inflammation of lung tissue. These effects were related to its inhibition on MMPs
KeywordSMOOTH-MUSCLE-CELLS SEROTONIN TRANSPORTER HYPERTENSION METALLOPROTEINASES COLLAGENASE EXPRESSION PROTECTS extracellular matrix inflammation pulmonary arterial hypertension selective serotonin reuptake inhibitor
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:4124334
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/148872
Collection中国科学院金属研究所
Affiliation1.中国科学院金属研究所
2.Zhongshan City Peoples Hosp, Department Pharm, Zhongshan 528403, Peoples R China
Recommended Citation
GB/T 7714
Li Xueqin,Wang Hanming,Yang Chunguang,et al. Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats[J]. ACTA PHARMACOLOGICA SINICA,2011,32(2):217-222.
APA Li Xueqin,Wang Hanming,Yang Chunguang,Zhang Xinhua,Han Dandan,&Wang Huailiang.(2011).Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats.ACTA PHARMACOLOGICA SINICA,32(2),217-222.
MLA Li Xueqin,et al."Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats".ACTA PHARMACOLOGICA SINICA 32.2(2011):217-222.
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