Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives

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	Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives
Alternative Title	Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives
	Li Fengran; Liu Yang; Wang Shuai; Wei Gaofei; Cheng Maosheng
	2016
Source Publication	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
ISSN	1005-9040
Volume	32 Issue:6 Pages:938-942
Abstract	Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1,2,3-triazolyl methyl moiety were synthesized via the method of Copper(I)-catalyzed Huisgen cycloaddition. The cytotoxicity evaluation results of these compounds against five human tumor cell lines show that most of these compounds presented potent activity and selectivity against A375-S2 and HT1080 cells. Compound 6c, with a p-NO2 at the bezene ring, possesses the best inhibitory activity against A375-S2( IC50=2.82 mu mol/L) and HT1080( IC50= 1.69 mu mol/L).
Other Abstract	Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1,2,3-triazolyl methyl moiety were synthesized via the method of Copper(I)-catalyzed Huisgen cycloaddition. The cytotoxicity evaluation results of these compounds against five human tumor cell lines show that most of these compounds presented potent activity and selectivity against A375-S2 and HT1080 cells. Compound 6c, with a p-NO_2 at the bezene ring, possesses the best inhibitory activity against A375-S2(IC_(50)=2.82 μmol/L) and HT1080(IC_(50)=1.69 μmol/L).
Keyword	OLEANOLIC ACID BIOLOGICAL EVALUATION AGENTS 3-Oxo-oleanolic acid 1,2,3-Triazole Tumor cytotoxicity
Indexed By	CSCD
Language	英语
Funding Project	[National Natural Science Foundation of China] ; [Program for Liaoning Excellent Talents in University, China]
CSCD ID	CSCD:5868625
Citation statistics	Cited Times:1[CSCD] [CSCD Record]
Document Type	期刊论文
Identifier	http://ir.imr.ac.cn/handle/321006/149656
Collection	中国科学院金属研究所
Affiliation	中国科学院金属研究所
Recommended Citation GB/T 7714	Li Fengran,Liu Yang,Wang Shuai,et al. Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2016,32(6):938-942.
APA	Li Fengran,Liu Yang,Wang Shuai,Wei Gaofei,&Cheng Maosheng.(2016).Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,32(6),938-942.
MLA	Li Fengran,et al."Synthesis and Tumor Cytotoxicity of Novel 1,2,3-Triazole-substituted 3-Oxo-oleanolic Acid Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 32.6(2016):938-942.

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