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Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats
Alternative TitleInhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats
Liu Zhenning; Zhao Min; Zheng Qiang; Zhao Hongyu; Hou Weijian; Bai Shuling
2013
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume34Issue:10Pages:1317-1324
AbstractAim: To investigate the effects of the PPAR-gamma agonist rosiglitazone on acute lung injury induced by the herbicide paraquat (PQ) and the underlying mechanisms of action.
Other AbstractAim: To investigate the effects of the PPAR-γ agonist rosiglitazone on acute lung injury induced by the herbicide paraquat (PQ) and the underlying mechanisms of action. Methods: Male Sprague-Dawley rats were injected with PQ (20 mg Results: At 72 h after PQ exposure, the untreated rats showed a 100% cumulative mortality, whereas no death was observed in rosiglitazone-pretreated rats. Moreover, rosiglitazone pretreatment dose-dependently attenuated PQ-induced lung edema and lung histopathological changes. The pretreatment significantly reduced the levels of TNF-α, IL-1β and MDA, increased SOD activity in the peripheral blood of PQ-treated rats. The pretreatment also efficiently activated PPAR-γ, induced Nrf2 expression and inhibited NF-κB activation in the lung tissues of PQ-treated rats. Furthermore, the pretreatment dose-dependently inhibited IκB-α degradation and phosphorylation, thus inhibiting NF-κB activation. Conclusion: Pretreatment with rosiglitazone protects rats against PQ-induced acute lung injury by activating PPAR-γ, inducing Nrf2 expression and inhibiting NF-κB activation.
KeywordACTIVATED-RECEPTOR-GAMMA NRF2 ENHANCES SUSCEPTIBILITY INFLAMMATORY RESPONSE LIPID-PEROXIDATION MICE PROTECTION INTOXICATION ANTIOXIDANTS HETERODIMER EXPRESSION rosiglitazone herbicide paraquat acute lung injury PPAR-gamma NF-kappa B Nrf2 toxicity
Indexed ByCSCD
Language英语
Funding Project[National Natural Science Foundation of China]
CSCD IDCSCD:4935195
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/152654
Collection中国科学院金属研究所
Affiliation中国科学院金属研究所
Recommended Citation
GB/T 7714
Liu Zhenning,Zhao Min,Zheng Qiang,et al. Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats[J]. ACTA PHARMACOLOGICA SINICA,2013,34(10):1317-1324.
APA Liu Zhenning,Zhao Min,Zheng Qiang,Zhao Hongyu,Hou Weijian,&Bai Shuling.(2013).Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats.ACTA PHARMACOLOGICA SINICA,34(10),1317-1324.
MLA Liu Zhenning,et al."Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats".ACTA PHARMACOLOGICA SINICA 34.10(2013):1317-1324.
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