| Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats | |
| Alternative Title | Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats |
| Zhao Longshan; Yin Ran; Wei Binbin; Li Qing; Jiang Zhenyuan; Chen Xiaohui; Bi Kaishun | |
| 2012 | |
| Source Publication | ACTA PHARMACOLOGICA SINICA
 |
| ISSN | 1671-4083 |
| Volume | 33Issue:11Pages:1348-1352 |
| Abstract | Aim: To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration. |
| Other Abstract | Aim: To compare the pharmacokinetic parameters of cefuroxime lysine, a new second-generation of cephalosporin antibiotics, after intravenous (IV), intraperitoneal (IP), or intramuscular (IM) administration. Methods: Twelve male and 12 virgin female Sprague-Dawley rats, weighing from 200 to 250 g, were divided into three groups ( n =4 for each gender in each group). The rats were administered a single dose (67.5 mg Results: After IV, IP or IM administration, the plasma cefuroxime lysine disposition was best described by a tri-compartmental, bi-compartmental or mono-compartmental open model, respectively, with first-order elimination. The plasma concentration profiles were similar through the 3 administration routes. The distribution process was rapid after IV administration t 1 , 0.10±0.11 h vs 1.36±0.65 and 1.25±1.01 h. The AUMC 0–∞ is markedly larger, and mean residence time (MRT) is greatly longer after IP administration than that in IV, or IM routes (AUMC 0–∞ : 55.33±20.34 vs 16.84±4.85 and 36.17±13.24 mg·h 2 vs 0.37±0.07 h and 0.65±0.05 h). The C max after IM injection was significantly higher than that in IP injection (73.51±12.46 vs 49.09±7.06 mg 0–∞ in male rats were significantly higher than that in female rats after IM administration (66.38±16.5 vs 44.23±6.37 mg·h Conclusion: Cefuroxime lysine shows quick absorption after IV injection, a long retension after IP injection, and a high C max after IM injection. After IM administration the AUC 0–∞ in male rats was significantly larger than that in female rats. |
| Keyword | ANTIBACTERIAL ACTIVITY LIQUID-CHROMATOGRAPHY MODEL BIOAVAILABILITY ANTIBIOTICS ELIMINATION PLASMA DOSAGE AXETIL CATS cefuroxime lysine intravenous administration intramuscular administration intraperitoneal administration pharmacokinetics |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Project | [National Key Scientific Project for New Drug Discovery and Development] |
| CSCD ID | CSCD:4669573 |
| Citation statistics |
Cited Times:2[CSCD]
[CSCD Record]
|
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/154035 |
| Collection | 中国科学院金属研究所 |
| Affiliation | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Zhao Longshan,Yin Ran,Wei Binbin,et al. Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats[J]. ACTA PHARMACOLOGICA SINICA,2012,33(11):1348-1352. |
| APA | Zhao Longshan.,Yin Ran.,Wei Binbin.,Li Qing.,Jiang Zhenyuan.,...&Bi Kaishun.(2012).Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats.ACTA PHARMACOLOGICA SINICA,33(11),1348-1352. |
| MLA | Zhao Longshan,et al."Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal, and intramuscular administration to rats".ACTA PHARMACOLOGICA SINICA 33.11(2012):1348-1352. |
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