Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats

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	Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats
其他题名	Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats
	Shang Wen 1; Han Ping 1; Yang Chengbing 1; Gu Xiaowen 1; Zhang Wei 1; Xu Liping 1; Fu Shouting 1; Su Dingfeng 1; Xie Hehui 1
	2011
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	1671-4083
卷号	32 期号:9 页码:1109-1115
摘要	Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR).
其他摘要	Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR). Methods: The rats were administered amlodipine (1 mg·kg ?1 ·d ?1 ) alone, irbesartan (10 mg·kg ?1 ·d ?1 ) alone, or the combination of the two drugs for 4 months. The drugs were mixed into the rat chow. Blood pressure (BP) was continuously monitored in conscious animals. After the determination of BRS, the rats were killed for morphological evaluation of organ damages. Results: The combination of low-dose irbesartan and amlodipine had statistically significant synergism on reduction of BP and BPV, amelioration of BRS and organ protection in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was associated with the decrease in systolic BPV ( r =0.665, P <0.01); the decrease in aortic hypertrophy was associated with the increase in BRS ( r =0.656, P <0.01); and the amelioration in renal lesion was associated with the increase in BRS ( r =0.763, P <0.01) and the decrease in systolic BPV ( r =0.706, P <0.01). Conclusion: Long-term treatment with a combination of low-doses of amlodipine and irbesartan showed significant synergism on reduction of BP and BPV, restoration of BRS and organ protection in SHR. Besides BP reduction, the enhancement of BRS and reduction of BPV might contribute to the organ protection.
关键词	BLOOD-PRESSURE VARIABILITY SINOAORTIC-DENERVATED RATS CALCIUM-CHANNEL BLOCKADE BAROREFLEX SENSITIVITY HEART-RATE VENTRICULAR HYPERTROPHY BARORECEPTOR REFLEX ARTERIAL-PRESSURE NERVOUS-SYSTEM CONSCIOUS RATS hypertension spontaneously hypertensive rats (SHR) amlodipine irbesartan hypertension end organ damage blood pressure variability baroreflex sensitivity
收录类别	CSCD
语种	英语
资助项目	[National Science and Technology Major Project] ; [National Natural Science Foundation of China]
CSCD记录号	CSCD:4335557
引用统计	被引频次：3[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157344
专题	中国科学院金属研究所
作者单位	1.安徽肥东花生原种场 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Shang Wen,Han Ping,Yang Chengbing,et al. Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats[J]. ACTA PHARMACOLOGICA SINICA,2011,32(9):1109-1115.
APA	Shang Wen.,Han Ping.,Yang Chengbing.,Gu Xiaowen.,Zhang Wei.,...&Xie Hehui.(2011).Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats.ACTA PHARMACOLOGICA SINICA,32(9),1109-1115.
MLA	Shang Wen,et al."Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats".ACTA PHARMACOLOGICA SINICA 32.9(2011):1109-1115.