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Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats
Alternative TitleEffects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats
Wang Jin1; Shen Fuming1; Wang Minwei1; Su Dingfeng1
2006
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume27Issue:8Pages:1013-1017
AbstractAim: The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure (BP) and blood pressure variability (BPV) in conscious sinoaortic-denervated (SAD) rats.
Other AbstractAim: The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure (BP) and blood pressure variability (BPV) in conscious sinoaortic-denervated (SAD) rats. Methods: Seventy-two SAD rats were randomly divided into nine groups. They were respectively given nifedipine 3 mg/kg, nitrendipine 5 mg/kg, amlodipine 1 mg/kg, clonidine 10 μg/kg, prazosin 0.5 mg/kg, atenolol 20 mg/kg, telmisartan 20 mg/kg, hydrochlorothiazide 40 mg/kg or captopril 50 mg/kg. The drugs were given via a catheter previously implanted into the stomach. BP was recorded for 5 h from 1 h before drug administration to 4 h after drug administration in conscious, freely moving rats. Results: It was found that all these nine drugs significantly decreased BP in SAD rats. Six of these drugs (nifedipine, nitrendipine, amlodipine, clonidine, prazosin and atenolol) significantly decreased BPV in SAD rats, but the remaining three drugs did not. Clonidine and atenolol increased the heart period and the others did not. No drugs affected the heart period variability. Conclusion: Among nine antihypertensive drugs from different classes, calcium antagonists and sympathetic inhibitors decreased BPV in SAD rats.
KeywordSPONTANEOUSLY HYPERTENSIVE-RATS END-ORGAN DAMAGE BAROREFLEX REDUCTION NITRENDIPINE KETANSERIN ATENOLOL TRIAL antihypertensive drugs blood pressure blood pressure variability sinoaortic denervation
Indexed ByCSCD
Language英语
CSCD IDCSCD:2462244
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/157707
Collection中国科学院金属研究所
Affiliation1.Second Mil Med University
2.中国科学院金属研究所
Recommended Citation
GB/T 7714
Wang Jin,Shen Fuming,Wang Minwei,et al. Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats[J]. ACTA PHARMACOLOGICA SINICA,2006,27(8):1013-1017.
APA Wang Jin,Shen Fuming,Wang Minwei,&Su Dingfeng.(2006).Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats.ACTA PHARMACOLOGICA SINICA,27(8),1013-1017.
MLA Wang Jin,et al."Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats".ACTA PHARMACOLOGICA SINICA 27.8(2006):1013-1017.
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