Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats

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	Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats
其他题名	Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats
	Wang Jin 1; Shen Fuming 1; Wang Minwei 1; Su Dingfeng 1
	2006
发表期刊	ACTA PHARMACOLOGICA SINICA
ISSN	1671-4083
卷号	27 期号:8 页码:1013-1017
摘要	Aim: The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure (BP) and blood pressure variability (BPV) in conscious sinoaortic-denervated (SAD) rats.
其他摘要	Aim: The present work was designed to investigate the effects of nine commonly used antihypertensive drugs on blood pressure (BP) and blood pressure variability (BPV) in conscious sinoaortic-denervated (SAD) rats. Methods: Seventy-two SAD rats were randomly divided into nine groups. They were respectively given nifedipine 3 mg/kg, nitrendipine 5 mg/kg, amlodipine 1 mg/kg, clonidine 10 μg/kg, prazosin 0.5 mg/kg, atenolol 20 mg/kg, telmisartan 20 mg/kg, hydrochlorothiazide 40 mg/kg or captopril 50 mg/kg. The drugs were given via a catheter previously implanted into the stomach. BP was recorded for 5 h from 1 h before drug administration to 4 h after drug administration in conscious, freely moving rats. Results: It was found that all these nine drugs significantly decreased BP in SAD rats. Six of these drugs (nifedipine, nitrendipine, amlodipine, clonidine, prazosin and atenolol) significantly decreased BPV in SAD rats, but the remaining three drugs did not. Clonidine and atenolol increased the heart period and the others did not. No drugs affected the heart period variability. Conclusion: Among nine antihypertensive drugs from different classes, calcium antagonists and sympathetic inhibitors decreased BPV in SAD rats.
关键词	SPONTANEOUSLY HYPERTENSIVE-RATS END-ORGAN DAMAGE BAROREFLEX REDUCTION NITRENDIPINE KETANSERIN ATENOLOL TRIAL antihypertensive drugs blood pressure blood pressure variability sinoaortic denervation
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:2462244
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/157707
专题	中国科学院金属研究所
作者单位	1.Second Mil Med University 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Wang Jin,Shen Fuming,Wang Minwei,et al. Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats[J]. ACTA PHARMACOLOGICA SINICA,2006,27(8):1013-1017.
APA	Wang Jin,Shen Fuming,Wang Minwei,&Su Dingfeng.(2006).Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats.ACTA PHARMACOLOGICA SINICA,27(8),1013-1017.
MLA	Wang Jin,et al."Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats".ACTA PHARMACOLOGICA SINICA 27.8(2006):1013-1017.