Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant

IMR OpenIR

	Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant
	Huang, Yong; Zhang, Xuejiao; Qiao, Haixia; Hao, Min; Zhang, Honglei; Xu, Zhiwei; Zhang, Xiaoyun; Pang, Xiaofeng; Lin, He; xfpang@aliyun.com; 1395004110@qq.com
	2016
发表期刊	CERAMICS INTERNATIONAL
ISSN	0272-8842
卷号	42 期号:1 页码:1903-1915
摘要	In this study, zinc-doped fluoridated hydroxyapatite (ZnFHA) nano-composite coatings were deposited on the surface of commercially pure titanium (Ti-cp) via electrolytic deposition technique. The phase composition, crystallite size, microstructure, and elemental composition of coated specimens were characterized using different techniques including Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis respectively. The influence of coatings on the corrosion behaviour of the specimens was determined by potentiodynamic polarisation in simulated body fluid. In vitro biocompatibility tests, MTT and alkaline phosphatase (ALP) were also employed to assess the cytocompatibility of ZnFHA coating with osteoblast-like MC3T3-E1 cells. Results demonstrated that zinc and fluoride were successfully incorporated into apatite lattice structure. Co-doping of Zn2+ and F- ions decreased hydroxyapatite unit cell volume and grain sizes. Obtained coatings were totally crack-free and dense, which led to decrease in corrosion current densities of Ti-cp in physiological solutions. In addition, cytocompatibility tests demonstrated a good osteoblast proliferation and spreading on ZnFHA. More importantly, results showed that the Zn/F-doping can promote ALP expression, which is a probable effect of a combination of nanostructured surface effects and ion release (Zn2+ and F-). Overall, the ZnFHA coated Ti-cp possesses favourable corrosion resistance and cytocompatibility for the application as biomedical implant material. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
部门归属	[huang, yong ; zhang, xuejiao ; qiao, haixia ; hao, min ; xu, zhiwei ; zhang, xiaoyun] hebei north univ, coll lab med, zhangjiakou 075000, peoples r china ; [huang, yong ; pang, xiaofeng] univ elect sci & technol china, inst life sci & technol, chengdu 610054, peoples r china ; [zhang, honglei] hebei univ, coll chem environm sci, baoding 071000, peoples r china ; [pang, xiaofeng] chinese acad sci, int ctr mat phys, shenyang 110015, peoples r china ; [lin, he] ludong univ, sch chem & mat sci, yantai 264025, peoples r china
关键词	Films Corrosion Apatite Biomedical Applications
资助者	Key Project of Science and Technology of Hebei Colleges [ZD2015124]; Natural Science Foundation of Hebei North University; High-level Scientific Research Foundation of Hebei North University; National Basic Research Program of China ("973" Program) [2011CB503700]
收录类别	sci
语种	英语
WOS记录号	WOS:000365367000116
引用统计	被引频次：66[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/74693
专题	中国科学院金属研究所
通讯作者	xfpang@aliyun.com; 1395004110@qq.com
推荐引用方式 GB/T 7714	Huang, Yong,Zhang, Xuejiao,Qiao, Haixia,et al. Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant[J]. CERAMICS INTERNATIONAL,2016,42(1):1903-1915.
APA	Huang, Yong.,Zhang, Xuejiao.,Qiao, Haixia.,Hao, Min.,Zhang, Honglei.,...&1395004110@qq.com.(2016).Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant.CERAMICS INTERNATIONAL,42(1),1903-1915.
MLA	Huang, Yong,et al."Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant".CERAMICS INTERNATIONAL 42.1(2016):1903-1915.