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Nasal mucosal inhalation of amyloid-beta peptide 3-10 defective adenovirus attenuates cytotoxicity induced by beta-amyloid (1-42) 期刊论文
NEURAL REGENERATION RESEARCH, 2014, 卷号: 9, 期号: 8, 页码: 872-877
作者:  Jiang Tongzi;  Guo Wanshu;  Sha Sha;  Xing Xiaona;  Guo Rong;  Cao Yunpeng
收藏  |  浏览/下载：140/0  |  提交时间：2021/02/02
ALZHEIMERS-DISEASE  TRANSGENIC MICE  TANDEM REPEATS  MOUSE MODEL  IMMUNIZATION  VACCINATION  MEMORY  IMMUNOTHERAPY  ANTIBODIES  DECLINE  nerve regeneration  neurodegenerative disease  Alzheimer's disease  immunotherapy  amyloid-beta peptide vaccine  cytokines  humoral immunity  inflammation  NSFC grant  neural regeneration  
Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease 期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 卷号: 45, 期号: 8, 页码: 613-621
作者:  Li Xiaoman;  Hong Lin;  Coughlan Kathleen;  Wang Liang;  Cao Liu;  Tang Jordan
收藏  |  浏览/下载：116/0  |  提交时间：2021/02/02
AMYLOID PRECURSOR PROTEIN  BETA-SECRETASE BACE1  GATED SODIUM-CHANNELS  CLEAVING ENZYME  GGA PROTEINS  ASPARTYL PROTEASE  NEURONAL-ACTIVITY  GENETIC DELETION  CYTOSOLIC DOMAIN  ALPHA-SECRETASE  memapsin 2  BACE1  beta-amyloid  subsite specificity  activity prediction  
Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's disease 期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 卷号: 45, 期号: 8, 页码: 613-621
作者:  Li Xiaoman;  Hong Lin;  Coughlan Kathleen;  Wang Liang;  Cao Liu;  Tang Jordan
收藏  |  浏览/下载：115/0  |  提交时间：2021/02/02
AMYLOID PRECURSOR PROTEIN  BETA-SECRETASE BACE1  GATED SODIUM-CHANNELS  CLEAVING ENZYME  GGA PROTEINS  ASPARTYL PROTEASE  NEURONAL-ACTIVITY  GENETIC DELETION  CYTOSOLIC DOMAIN  ALPHA-SECRETASE  memapsin 2  BACE1  beta-amyloid  subsite specificity  activity prediction  
Neural cell injury microenvironment induces neural differentiation of human umbilical cord mesenchymal stem cells 期刊论文
NEURAL REGENERATION RESEARCH, 2012, 卷号: 7, 期号: 34, 页码: 2689-2697
作者:  Zhou Jin;  Tian Guoping;  Wang Jinge;  Luo Xiaoguang;  Zhang Siyang;  Li Jianping;  Li Li;  Xu Bing;  Zhu Feng;  Wang Xia;  Jia Chunhong;  Zhao Weijin;  Zhao Danyang;  Xu Aihua
收藏  |  浏览/下载：129/0  |  提交时间：2021/02/26
BETA-AMYLOID NEUROTOXICITY  ALZHEIMERS-DISEASE  CHOLINE-ACETYLTRANSFERASE  RAT MODEL  IN-VITRO  REGENERATIVE MEDICINE  HIPPOCAMPAL-NEURONS  COGNITIVE FUNCTION  SCHWANN-CELLS  BONE-MARROW  stem cell  umbilical cord mesenchymal stem cell  co-culture  induction  differentiation  neural cell  microtubule-associated protein 2  injured cell  Transwell  neural regeneration  regeneration  
Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10 期刊论文
NEURAL REGENERATION RESEARCH, 2011, 卷号: 6, 期号: 26, 页码: 2005-2012
作者:  Guo Rong;  Huang Kui;  Jiang Tongzi;  Li Jian;  Li Yu;  Xing Xiaona;  Cao Yunpeng
收藏  |  浏览/下载：114/0  |  提交时间：2021/02/26
ALZHEIMERS-DISEASE  MOUSE MODEL  FOLLOW-UP  PEPTIDE  NEUROPATHOLOGY  A-BETA-1-40/42  VACCINATION  IMMUNOGENS  PATHOLOGY  PROTEIN  Alzheimer's disease  immunotherapy  gene vaccine  amyloid plaque  T cell immunity response  neural regeneration  
Synthesis and biological activity of 3,6-diaryl-7H-thiazolo3,2-b 1,2,4triazin-7-one derivatives as novel acetylcholinesterase inhibitors 期刊论文
SCIENCE CHINA-CHEMISTRY, 2010, 卷号: 53, 期号: 11, 页码: 2297-2303
作者:  Jin Zhe;  Yang Liu;  Xu HeNan;  Huang ErFang;  Wan David ChiCheong;  Li Shuo;  Lin HuangQuan;  Hu Chun
收藏  |  浏览/下载：119/0  |  提交时间：2021/02/26
AMYLOID-BETA  ENZYME  DESIGN  acetylcholinesterase  inhibitor  thiazole  1,2,4-triazine  heterocycle  synthesis  docking  MVD  
Protective effect of cyclophilin A against Alzheimer's amyloid beta-peptide (25-35)-induced oxidative stress in PC12 cells 期刊论文
CHINESE MEDICAL JOURNAL, 2009, 卷号: 122, 期号: 6, 页码: 716-724
作者:  Ge Yusong;  Teng Weiyu;  Zhang Chaodong
收藏  |  浏览/下载：95/0  |  提交时间：2021/02/02
TRANS-ISOMERASE ACTIVITY  MITOCHONDRIAL DYSFUNCTION  A EXPRESSION  DIFFERENTIATION  ANTIOXIDANT  ACTIVATION  PROTEIN  LOCALIZATION  APOPTOSIS  PATHWAY  Alzheimer's disease  cyclophilin A  beta-amyloid  oxidative stress  apoptosis  
Cyclophilin A affects Bcl-2 and Bax expression following beta-amyloid fragment 25-35-induced injury to PC12 cells 期刊论文
NEURAL REGENERATION RESEARCH, 2008, 卷号: 3, 期号: 6, 页码: 585-588
作者:  Cheng Li;  Zhang Chaodong
收藏  |  浏览/下载：85/0  |  提交时间：2021/02/02
IN-VITRO  APOPTOSIS  PEPTIDE  MITOCHONDRIAL  INHIBITION  MELATONIN  NEURONS  DEATH  cyclophilin A  pheochromocytoma (PC12) cells  beta-amyloid fragment 25-35  Bcl-2  Bax  
Cyclophilin A affects Bcl-2 and Bax expression following beta-amyloid fragment 25-35-induced injury to PC12 cells 期刊论文
NEURAL REGENERATION RESEARCH, 2008, 卷号: 3, 期号: 6, 页码: 585-588
作者:  Cheng Li;  Zhang Chaodong
收藏  |  浏览/下载：92/0  |  提交时间：2021/02/02
IN-VITRO  APOPTOSIS  PEPTIDE  MITOCHONDRIAL  INHIBITION  MELATONIN  NEURONS  DEATH  cyclophilin A  pheochromocytoma (PC12) cells  beta-amyloid fragment 25-35  Bcl-2  Bax  
Changes in intracellular calcium in brain cells of aged rats 期刊论文
NEURAL REGENERATION RESEARCH, 2008, 卷号: 3, 期号: 9, 页码: 1026-1029
作者:  Li Yu;  Cao Yunpeng
收藏  |  浏览/下载：83/0  |  提交时间：2021/02/02
HIPPOCAMPAL CA1 NEURONS  SYNAPTIC PLASTICITY  ALZHEIMERS-DISEASE  SLOW AFTERHYPERPOLARIZATION  ENDOPLASMIC-RETICULUM  PYRAMIDAL NEURONS  AMYLOID-BETA  ESTROGEN  CA2+  DYSREGULATION  aged rats  neuron  intracellular calcium