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Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions 期刊论文
CANCER MANAGEMENT AND RESEARCH, 2020, 卷号: 12, 页码: 10411-10421
Authors:  Zeng, Guoming;  Jin, Libo;  Ying, Qinsi;  Chen, Haojie;  Thembinkosi, Murinda Charmaine;  Yang, Chunguang;  Zhao, Jinlong;  Ji, Hao;  Lin, Sue;  Peng, Renyi;  Zhang, Maolan;  Sun, Da
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cancer immunotherapy  Treg cells  FoxP3  targeting Treg cells  anti-cancer  
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions 期刊论文
CANCER MANAGEMENT AND RESEARCH, 2020, 卷号: 12, 页码: 10411-10421
Authors:  Zeng, Guoming;  Jin, Libo;  Ying, Qinsi;  Chen, Haojie;  Thembinkosi, Murinda Charmaine;  Yang, Chunguang;  Zhao, Jinlong;  Ji, Hao;  Lin, Sue;  Peng, Renyi;  Zhang, Maolan;  Sun, Da
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cancer immunotherapy  Treg cells  FoxP3  targeting Treg cells  anti-cancer  
Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect 期刊论文
Acta Pharmaceutica Sinica B, 2019, 卷号: 9, 期号: 4, 页码: 858-870
Authors:  Wu Hangyi;  Yu Miaorong;  Miao Yunqiu;  He Shufang;  Dai Zhuo;  Song Wenyi;  Liu Yuan;  Song Sha;  Ahmad Ejaj;  Wang Dongkai;  Gan Yong
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Therapeutics. Pharmacology  RM1-950  
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
Authors:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye;  Zhao YanFang;  Gong Ping
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TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity  
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
Authors:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye;  Zhao YanFang;  Gong Ping
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TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity  
Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 7, 页码: 941-949
Authors:  Sun Huiping;  Su Jinghan;  Meng Qingshuo;  Yin Qi;  Zhang Zhiwen;  Yu Haijun;  Zhang Pengcheng;  Wang Siling;  Li Yaping
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COMBINATION THERAPY  POLYMERIC MICELLES  GOLD NANORODS  DOXORUBICIN  RELEASE  NANOMEDICINE  NANOCARRIER  PACLITAXEL  INVASION  DELIVERY  breast cancer  4T1 mammalian breast cancer cells  metastasis  nanoparticles  silibinin  photothermal therapy  NIR laser irradiation  
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
Authors:  Lv Wenwen;  Qin Sining;  Chen Congqin;  Zhang Jinjie;  Ren Tianshu;  Xu Yongnan;  Zhao Qingchun
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ENDOTHELIAL GROWTH-FACTOR  DRUG-INDUCED APOPTOSIS  HEMATOLOGICAL MALIGNANCIES  ACTIN REORGANIZATION  ANTICANCER DRUG  BONE-MARROW  KINASE AKT  CANCER  THALIDOMIDE  MIGRATION  isoindolone  anticancer drug  leukemia  zebrafish  angiogenesis  apoptosis  AKT  GSK3 beta  
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
Authors:  Lv Wenwen;  Qin Sining;  Chen Congqin;  Zhang Jinjie;  Ren Tianshu;  Xu Yongnan;  Zhao Qingchun
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ENDOTHELIAL GROWTH-FACTOR  DRUG-INDUCED APOPTOSIS  HEMATOLOGICAL MALIGNANCIES  ACTIN REORGANIZATION  ANTICANCER DRUG  BONE-MARROW  KINASE AKT  CANCER  THALIDOMIDE  MIGRATION  isoindolone  anticancer drug  leukemia  zebrafish  angiogenesis  apoptosis  AKT  GSK3 beta  
Synthesis and in vitro antitumor activity of novel diaryl urea derivatives 期刊论文
CHINESE CHEMICAL LETTERS, 2013, 卷号: 24, 期号: 5, 页码: 386-388
Authors:  Zhao YanFang;  Liu ZiJian;  Zhai Xin;  Ge DanDan;  Huang Qiang;  Gong Ping
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RECEPTOR TYROSINE KINASES  INHIBITOR  DISCOVERY  SORAFENIB  Diaryl ureas  Synthesis  Antitumor activity in vitro  
A novel sulfonamide agent, MPSP-001, exhibits potent activity against human cancer cells in vitro through disruption of microtubule 期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 2, 页码: 261-270
Authors:  Liu Zulong;  Tian Wei;  Wang Yong;  Kuang Shan;  Luo Xiaomin;  Yu Qiang
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PHASE-I  ANTITUMOR-ACTIVITY  ANTICANCER AGENT  BINDING  APOPTOSIS  E7070  COLCHICINE  DISCOVERY  HMN-214  CAMPTOTHECIN  MPSP-001  sulfonamide  anticancer drug  microtubules  tubulin  mitotic spindle  drug resistance  drug synergism